IUPAC_name = 4,9-dihydro-4-(1-methyl-4-piperidinylidene)- 10H-benzocyclohepta [1,2-b] thiopen-10-one

width = 200
CAS_number = 34580-14-8
ATC_prefix = R06
ATC_suffix = AX17
ATC_supplemental = ATC|S01|GX08
PubChem = 3827
DrugBank = APRD01061
C = 19 |H = 19 |N = 1 |O = 1 |S = 1
molecular_weight = 309.426 g/mol
bioavailability = 60%
protein_bound = 75%
metabolism = Hepatic
elimination_half-life = 12 Hours
pregnancy_category =
legal_US = OTC
legal_status =
routes_of_administration = Oral, Eye Drops

Ketotifen fumarate (ophthalmic solutions marketed under the brand name Zaditor (Novartis) and Alaway (Bausch and Lomb)) is an H1-antihistamine/mast cell stabilizer available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis, or the itchy red eyes caused by allergies. In its form, it is used to prevent asthma attacks. Side effects include drowsiness, weight gain, dry mouth, irritability, and increased nosebleeds.

General Information

Ketotifen relieves and prevents eye itchiness and/or irritation associated with most seasonal allergies. It starts working within minutes after administering the drops. The drug has not been studied in children under 3. The mean elimination half life is 12 hours. [cite journal |journal=Biopharm Drug Dispos |year=1992 |month=May |volume=13 |issue=4 |pages=255–62 |title=Pharmacokinetics of ketotifen after oral administration to healthy male subjects |author=Grahnén A |coauthors=Lönnebo A, Beck O, Eckernäs SA, Dahlström B, Lindström B |pmid=1600111 |doi=10.1002/bdd.2510130404]


External links

* [ Zaditor web site]
* [ Alaway web site]

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