Alfuzosin

drugbox
IUPAC_name = "N"- [3- [(4-amino-6,7-dimethoxy-quinazolin-2-yl)- methyl-amino] propyl] tetrahydrofuran- 2-carboxamide



CAS_number = 81403-80-7
ATC_prefix = G04
ATC_suffix = CA01
PubChem = 2092
ChemSpiderID = 2008
DrugBank = APRD00490
C = 19 | H = 27 | N = 5 | O = 4
molecular_weight = 389.449 g/mol
bioavailability = 49%
protein_bound = 82%-90%
metabolism = Hepatic (CYP3A4-mediated)
elimination_half-life = 10 hours
excretion = Fecal (69%) and renal (24%)
pregnancy_AU = B2
pregnancy_US = B
legal_UK = POM
legal_US = Rx-only
routes_of_administration = Oral

Alfuzosin (INN, provided as the hydrochloride salt) is an α1 receptor antagonist used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.

Alfuzosin is marketed in the United States by Sanofi Aventis under the brand name Uroxatral and elsewhere under the tradename Xatral. Alfuzosin was approved by the FDA for treatment of BPH in June 2003.

Side effects

The most common side effects are dizziness (due to postural hypotension), upper respiratory tract infection, headache, and fatigue.

Contraindications

Alfuzosin should be used with caution in patients with severe renal insufficiency, and should not be prescribed to patients with a known history of QT prolongation who are taking medications known to prolong the QT interval.


External links

* [http://www.uroxatral.com/ Uroxatral] (manufacturer's website)
* [http://www.meds-help.com/alfuzosin/ Alfuzosin] (patient information)


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • alfuzosin — n. an alpha blocker commonly used in the treatment of men with lower urinary tract symptoms thought to be due to benign prostatic hyperplasia (see prostate gland). Trade name: Xatral …   Medical dictionary

  • alfuzosin — n. an alpha blocker commonly used in the treatment of men with lower urinary tract symptoms thought to be due to benign prostatic hyperplasia (see prostate gland). Trade names: Xatral …   The new mediacal dictionary

  • alfuzosin hydrochloride — al·fu·zo·sin hy·dro·chlo·ride (al fuґzo sin) an alpha adrenergic blocking agent that is selective for the alpha1 adrenergic receptors of the lower urinary tract, causing relaxation of smooth muscles of the bladder neck and prostate; used to… …   Medical dictionary

  • Adrenergic receptor — Epinephrine Norepinephrine The adrenergic receptors (or adrenoceptors) are a class of met …   Wikipedia

  • Doxazosin — Systematic (IUPAC) name (RS) 2 {4 [(2,3 dihydro 1,4 benzodioxin 2 yl)carbonyl]piperazin 1 yl} 6,7 dimethoxyquinazolin 4 amine Clinical data Trade names …   Wikipedia

  • Tamsulosin — Systematic (IUPAC) name (R) 5 (2 {[2 (2 ethoxyphenoxy)ethyl]amino}propyl) 2 methoxybenzene 1 sulfonamide Clinical data …   Wikipedia

  • Guanethidine — Systematic (IUPAC) name 2 [2 (azocan 1 yl)ethyl]guanidine Clinical data AHFS/Drugs.com …   Wikipedia

  • Treatment of multiple sclerosis — Several therapies for multiple sclerosis (MS) exist, although there is no known cure. Multiple sclerosis is a chronic inflammatory demyelinating disease that affects the central nervous system (CNS). The most common initial course of the disease… …   Wikipedia

  • Multiple sclerosis signs and symptoms — Main symptoms of multiple sclerosis. Multiple sclerosis can cause a variety of symptoms: changes in sensation (hypoesthesia), muscle weakness, abnormal muscle spasms, or difficulty moving; difficulties with coordination and balance; problems in… …   Wikipedia

  • Alpha-1-Adrenozeptor — Die α1 Adrenozeptoren sind Gq/11 Protein gekoppelte Rezeptoren, die durch die Signalstoffe Adrenalin und Noradrenalin aktiviert werden. Sie werden auf Grund ihrer pharmakologischen Eigenschaften in vier Subtypen unterteilt: α1A, α1B, α1D und α1L …   Deutsch Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.