SR 59230A

chembox new
ImageFile=SR 59230A.svg
ImageSize=
IUPACName=(2"S")-1-(2-ethylphenoxy)-3-{ [(1"S")-1,2,3, 4-tetrahydronaphthalen-1-yl] amino}propan-2-ol
OtherNames=
Section1=Chembox Identifiers
CASNo=174689-39-5
PubChem=5311452
SMILES=CCC1=CC=CC=C1OCC(CNC2CCCC3=CC=CC=C23)O

Section2=Chembox Properties
C=21|H=27|N=1|O=2
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=

Section3=Chembox Hazards
MainHazards=
FlashPt=
Autoignition=

SR 59230A is a selective antagonist of the beta-3 adrenergic receptor.cite journal | author = Nisoli E, Tonello C, Landi M, Carruba MO | title = Functional studies of the first selective β3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes | journal = Mol. Pharmacol. | volume = 49 | issue = 1 | pages = 7–14 | year = 1996 | pmid = 8569714 | doi = | issn = ] cite journal |author=Bellantuono V, Cassano G, Lippe C |title=The adrenergic receptor subtypes present in frog (Rana esculenta) skin |journal=Comp. Biochem. Physiol. C Toxicol. Pharmacol. |volume=148 |issue=2 |pages=160–4 |year=2008 |month=August |pmid=18544474 |doi=10.1016/j.cbpc.2008.05.001 |url=http://linkinghub.elsevier.com/retrieve/pii/S1532-0456(08)00076-8] cite journal |author=Rickenbacher A, Seiler R, Honegger U, Shaw SG, Balsiger BM |title=Role of beta1-, beta2-, and beta3-adrenoceptors in contractile hypersensitivity in a model of small bowel transplantation |journal=Surgery |volume=143 |issue=1 |pages=94–102 |year=2008 |month=January |pmid=18154937 |doi=10.1016/j.surg.2007.06.034 |url=http://linkinghub.elsevier.com/retrieve/pii/S0039-6060(07)00443-6]

Although it is usually considered a selective agent, some have questioned this categorization.cite journal |author=Leblais V, Pourageaud F, Ivorra MD, Guibert C, Marthan R, Muller B |title=Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery |journal=J. Pharmacol. Exp. Ther. |volume=309 |issue=1 |pages=137–45 |year=2004 |month=April |pmid=14718590 |doi=10.1124/jpet.103.061192 |url=http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=14718590]

References


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Adrenergic receptor — Epinephrine Norepinephrine The adrenergic receptors (or adrenoceptors) are a class of met …   Wikipedia

  • Beta blocker — Beta blockers Drug class Skeletal formula of propranolol, the first clinically successful beta blocker ATC code C07 …   Wikipedia

  • Guanethidine — Systematic (IUPAC) name 2 [2 (azocan 1 yl)ethyl]guanidine Clinical data AHFS/Drugs.com …   Wikipedia

  • Beta-3 adrenergic receptor — The beta 3 adrenergic receptor (β3 adrenoreceptor), also known as ADRB3, is an beta adrenergic receptor, and also denotes the human gene encoding it.cite web | title = Entrez Gene: ADRB1 adrenergic, beta 1 , receptor| url =… …   Wikipedia

  • Amphetamine — For other uses, see Amphetamine (disambiguation). Amphetamine Systematic (IUPAC) name …   Wikipedia

  • Dimethyltryptamine — Systematic (IUPAC) name 2 (1H indol 3 yl) N …   Wikipedia

  • Epinephrine — Adrenaline and Adrenalin redirect here. For other uses, see Adrenaline (disambiguation). (R) (–) L Epinephrine or (R) (–) L adrenaline …   Wikipedia

  • Monoamine oxidase inhibitor — MAOI redirects here. For the Easter Island statues, see Moai. Monoamine oxidase Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating… …   Wikipedia

  • Phenothiazine — Phenothiazine …   Wikipedia

  • Clozapine — Not to be confused with clonazepam or Klonopin. Clozapine Systematic (IUPAC) name …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.