NS-2664 Systematic (IUPAC) name 5-furan-3-yl-1-(3-imidazol-1-yl-phenyl)-1H-benzoimidazole Clinical data Pregnancy cat. ? Legal status ? Identifiers ATC code ? PubChem Chemical data Formula C20H14N4O Mol. mass 326.351 g/mol SMILES & (what is this?)
NS-2664 (LS-193,048) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company Neurosearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2664 is a potent but non-selective partial agonist at GABAA receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has potent anticonvulsant effects in animal studies, but a relatively short duration of action, and produces little sedative effects or physical dependence.
- ^ Mirza NR, Nielsen EØ. Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice? Journal of Pharmacology and Experimental Therapeutics. 2006 Mar;316(3):1378-85. PMID 16352707
Anxiolytics (N05B) GABAA PAMsAdinazolam • Alprazolam • Bretazenil • Bromazepam • Camazepam • Chlordiazepoxide • Clobazam • Clonazepam • Clorazepate • Clotiazepam • Cloxazolam • Diazepam • Ethyl Loflazepate • Etizolam • Fludiazepam • Halazepam • Imidazenil • Ketazolam • Lorazepam • Medazepam • Nordazepam • Oxazepam • Pinazepam • PrazepamAbecarnil • Adipiplon • Alpidem • CGS-8216 • CGS-9896 • CGS-13767 • CGS-20625 • Divaplon • ELB-139 • Fasiplon • GBLD-345 • Gedocarnil • L-838,417 • NS-2664 • NS-2710 • Ocinaplon • Pagoclone • Panadiplon • Pipequaline • RWJ-51204 • SB-205,384 • SL-651,498 • Taniplon • TP-003 • TP-13 • TPA-023 • Y-23684 • ZK-93423PyrazolopyridinesOthers α2δ VDCC Blockers 5-HT1A Agonists H1 Antagonists CRH1 Antagonists NK2 AntagonistsGR-159,897 • Saredutant MCH1 antagonistsATC-0175 • SNAP-94847 mGluR2/3 Agonists mGluR5 NAMs TSPO agonists σ1 agonistsAfobazole • Opipramol Others #WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase III This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.