CED-12

CED-12 is the "C. elegans" ortholog of the ELMO family of mammalian adaptor proteins. It interacts with CED-5 (the "C. elegans" ortholog of mammalian Dock180) to form a bipartite guanine nucleotide exchange factor which promotes cell migration and phagocytosis of apoptotic cells.cite journal | author = Gumienny TL, Brugnera E, Tosello-Trampont AC, "et al" | title = CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration | journal = Cell | volume = 107 | issue = 1 | pages = 27-41 | year = 2001 | month = June | pmid = 11595183 | pmc = | url = | issn = ]

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