Perospirone

Drugbox
IUPAC_name = (3a"S",7a"R")-2- [4- [4-(1,2-benzothiazol-3-yl)piperazin-1-yl] butyl] -3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione



CAS_number = 150915-41-6
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PubChem = 115368
DrugBank =
chemical_formula =
C=23 | H=30 | N=4 | O=2 | S=1
molecular_weight = 426.57 g/mol
smiles = C1CCC2C(C1)C(=O)N(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54
bioavailability =
protein_bound =
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legal_status = Rx-only
routes_of_administration = Oral

Perospirone (INN, marketed by Dainippon Sumitomo Pharma under the trade name Lullan) is an neuroleptic.

It is a 5-HT2 receptor antagonist.cite journal |author=Ohno Y, Ishibashi T, Okada K, Ishida K, Nakamura M |title=Effects of subchronic treatments with SM-9018, a novel 5-HT2 and D2 antagonist, on dopamine and 5-HT receptors in rats |journal=Prog. Neuropsychopharmacol. Biol. Psychiatry |volume=19 |issue=6 |pages=1091–101 |year=1995 |month=October |pmid=8584685 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/0278584695001999] Clinical trials show that extrapyramidal symptoms tend to occur less often and were generally milder than with haloperidol or mosapramine.cite journal |author=Onrust SV, McClellan K |title=Perospirone |journal=CNS Drugs |volume=15 |issue=4 |pages=329–37; discussion 338 |year=2001 |pmid=11463136 |doi= |url=]

References


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