Alvocidib


Alvocidib

chembox new
ImageFile=Alvocidib.pngImageSize=200px
IUPACName=2-(2-chlorophenyl)-5,7-dihydroxy-8- [(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl] -4-chromenone
OtherNames=
Section1=Chembox Identifiers
CASNo=
PubChem= 5287969
SMILES=CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O
MeSHName = Flavopiridol

Section2=Chembox Properties
Formula=C21H20ClNO5
MolarMass=401.8402
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=

Section3=Chembox Hazards
MainHazards=
FlashPt=
Autoignition=

Alvocidib (INN; also known as Flavopiridol or HMR-1275) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia. It has been studied also for the treatment of arthritis.cite journal |author=Sekine C, Sugihara T, Miyake S, "et al" |title=Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors |journal=J. Immunol. |volume=180 |issue=3 |pages=1954–61 |year=2008 |month=February |pmid=18209094 |doi= |url=http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=18209094]

References


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • alvocidib — noun A drug being researched for the treatment of chronic lymphocytic leukaemia and arthritis …   Wiktionary

  • Cyclin-dependent kinase — Schematic of the cell cycle. outer ring: I=Interphase, M=Mitosis; inner ring: M=Mitosis; G1=Gap phase 1; S=Synthesis; G2=Gap phase 2. The duration of mitosis in relation to the other phases has been exaggerated in this diagram Cyclin dependent… …   Wikipedia

  • Chemotherapy — A woman being treated with docetaxel chemotherapy for breast cancer. Cold mittens and wine coolers are placed on her hands and feet to reduce harm to her nails. Chemotherapy (sometimes cancer chemotherapy) is the treatment of cancer with an… …   Wikipedia

  • Paclitaxel — Systematic (IUPAC) name (2α,4α,5β,7β,10β,13α) 4,10 bis(acetyloxy) …   Wikipedia

  • Methotrexate — Amethopterin redirects here. Not to be confused with aminopterin. Methotrexate Systematic ( …   Wikipedia

  • Everolimus — Systematic (IUPAC) name dihydroxy 12 [(2R) 1 [(1S,3R,4R) 4 (2 hydroxyethoxy) 3 methoxycyclohexyl]propan 2 yl] 19,30 dimethoxy 15,17,21,23,29,35 hexamethyl 11,36 dioxa 4 azatricyclo[30.3.1.04,9]hexatriaconta 16,24,26,28 tetraene 2,3,10,14,20… …   Wikipedia

  • Tretinoin — Systematic (IUPAC) name retinoic acid …   Wikipedia

  • Celecoxib — Systematic (IUPAC) name 4 [5 (4 methylphenyl) 3 (trifluoromethyl) pyrazol 1 yl]benzenesulfonamide Clinical data Trade names …   Wikipedia

  • Cytarabine — Systematic (IUPAC) name 4 amino 1 [(2R,3S,4R,5R) 3,4 dihydroxy 5 (hydroxymethyl)oxolan 2 yl] pyrimidin 2 one Clinical data AHFS/Drugs.com …   Wikipedia

  • Vincristine — Systematic (IUPAC) name methyl (1R,9R,10S,11R,12R,19R) 11 (acetyloxy) Clinical data AHFS/Dr …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.