Procarbazine

Procarbazine
Systematic (IUPAC) name
N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide
Clinical data
Trade names Matulane
AHFS/Drugs.com monograph
MedlinePlus a682094
Pregnancy cat. D(AU) D(US)
Legal status Prescription only
Routes Oral (Gel Capsule), intravenous
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic, Renal
Half-life 10 minutes
Excretion Renal
Identifiers
CAS number 671-16-9
ATC code L01XB01
PubChem CID 4915
DrugBank APRD00695
ChemSpider 4746 YesY
UNII 35S93Y190K YesY
KEGG D08423 YesY
ChEMBL CHEMBL1321 YesY
Chemical data
Formula C12H19N3O 
Mol. mass 221.299 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Procarbazine (Matulane (US), Natulan (Canada), Indicarb (India) is an antineoplastic chemotherapy drug for the treatment of Hodgkin's lymphoma and certain brain cancers (such as Glioblastoma multiforme). It is a member of a group of medicines called alkylating agents. It gained FDA Approved in July 1969. The drug is metabolized and activated in the liver. It also inhibits MAO thus increasing the effects of sympathomimetics, TCAs, and tyramine.

Contents

Pharmacology

Its mechanism of action is not fully understood. Metabolism yields azo-procarbazine and hydrogen peroxide[citation needed] which results in the breaking of DNA strands.

Indications

When used to treat Hodgkin's Lymphoma, it is often delivered as part of the MOPP regimen that includes Mechlorethamine, Vincristine (tradename Oncovin), Prednisone, and Procarbazine. Alternatively, when used to treat certain brain tumors (malignant gliomas), it is often dosed as PCV when combined with Lomustine (often called CCNU) and Vincristine.

Procarbazine is also part of the more modern BEACOPP regimen used for Hodgkin's lymphoma.

Side Effects/ Adverse Reactions

When combined with ethanol, procarbazine may cause a disulfiram-like reaction in some patients. It also inhibits the liver's CYP450 microsomal system, which leads to an increased effect of barbiturates, phenothiazenes, and narcotics normally metabolized by the CYP450 enzymes. Has monamine oxidase inhibition properties (MAOI), and should not be taken with most antidepressants and certain migraine medications.

Inhibits MAO in the gastrointestinal system thus can cause hypertensive crises if associated with the ingestion of tyramine-rich foods such as aged cheeses.

Dose

Adult: 2–4 mg/kg/day either in a single dose or divided, given for 7 days then increased to 4–6 mg/kg/day until response is obtained or mylosupression occurs. Dose should be adjusted for renal (kidney) disease or hepatic (liver) disease.

Dosage Form

50 mg capsules.

References

External links


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • procarbazine — noun Etymology: propyl + carbamic acid + azine Date: 1965 an antineoplastic drug C12H19N3O that is a monoamine oxidase inhibitor used in the form of its hydrochloride especially in the palliative treatment of Hodgkin s disease …   New Collegiate Dictionary

  • procarbazine — pro·car·ba·zine (prō kärʹbə zēn) n. A potent antineoplastic drug, C12H19N3O, used primarily to treat advanced Hodgkin s disease.   [propyl + carbo + azine.] * * * …   Universalium

  • procarbazine — noun A particular drug used in chemotherapy …   Wiktionary

  • procarbazine — pro·car·ba·zine prō kär bə .zēn, zən n an antineoplastic drug that occurs as a white to yellowish crystalline powder, is a monoamine oxidase inhibitor, and is used in the form of its hydrochloride C12H19N3O·HCl esp. in the palliative treatment of …   Medical dictionary

  • procarbazine — pro·car·ba·zine …   English syllables

  • procarbazine — n. a drug that inhibits growth of cancer cells by preventing cell division and is used to treat such cancers as Hodgkin s disease. It is administered by mouth; side effects may include loss of appetite, nausea, myelosuppression, and rash …   The new mediacal dictionary

  • procarbazine — A drug that is used to treat cancer. It belongs to the family of drugs called alkylating agents …   English dictionary of cancer terms

  • procarbazine — noun an antineoplastic drug used to treat Hodgkin s disease • Hypernyms: ↑antineoplastic, ↑antineoplastic drug, ↑cancer drug …   Useful english dictionary

  • procarbazine hydrochloride — An antineoplastic agent. * * * pro·car·ba·zine hy·dro·chlo·ride (pro kahrґbə zēn) [USP] an alkylating agent specific for the S phase of the cell cycle used as an antineoplastic, primarily in combination with mechlorethamine, vincristine …   Medical dictionary

  • Mustargen Oncovin Procarbazine Prednisone — MOPP is a combination chemotherapy regimen used to treat Hodgkin s disease. The acronym is derived from the component drugs of the regimen: Mustargen (also known as mechlorethamine, mustine, nitrogen mustard, or MSD) Oncovin (also known as… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.