Procarbazine Systematic (IUPAC) name N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide Clinical data Trade names Matulane AHFS/Drugs.com MedlinePlus Pregnancy cat. D(AU) D(US) Legal status ℞ Prescription only Routes Oral (Gel Capsule), intravenous Pharmacokinetic data Bioavailability ? Metabolism Hepatic, Renal Half-life 10 minutes Excretion Renal Identifiers CAS number ATC code L01 PubChem DrugBank ChemSpider UNII KEGG ChEMBL Chemical data Formula C12H19N3O Mol. mass 221.299 g/mol SMILES & (what is this?)
Procarbazine (Matulane (US), Natulan (Canada), Indicarb (India) is an antineoplastic chemotherapy drug for the treatment of Hodgkin's lymphoma and certain brain cancers (such as Glioblastoma multiforme). It is a member of a group of medicines called alkylating agents. It gained FDA Approved in July 1969. The drug is metabolized and activated in the liver. It also inhibits MAO thus increasing the effects of sympathomimetics, TCAs, and tyramine.
When used to treat Hodgkin's Lymphoma, it is often delivered as part of the MOPP regimen that includes Mechlorethamine, Vincristine (tradename Oncovin), Prednisone, and Procarbazine. Alternatively, when used to treat certain brain tumors (malignant gliomas), it is often dosed as PCV when combined with Lomustine (often called CCNU) and Vincristine.
Procarbazine is also part of the more modern BEACOPP regimen used for Hodgkin's lymphoma.
Side Effects/ Adverse Reactions
When combined with ethanol, procarbazine may cause a disulfiram-like reaction in some patients. It also inhibits the liver's CYP450 microsomal system, which leads to an increased effect of barbiturates, phenothiazenes, and narcotics normally metabolized by the CYP450 enzymes. Has monamine oxidase inhibition properties (MAOI), and should not be taken with most antidepressants and certain migraine medications.
Inhibits MAO in the gastrointestinal system thus can cause hypertensive crises if associated with the ingestion of tyramine-rich foods such as aged cheeses.
Adult: 2–4 mg/kg/day either in a single dose or divided, given for 7 days then increased to 4–6 mg/kg/day until response is obtained or mylosupression occurs. Dose should be adjusted for renal (kidney) disease or hepatic (liver) disease.
50 mg capsules.
- Medline Plus Drug Information
- MOPP Treatment Regimen
- PCV Information
- Procarbazine Drug Information Provided by Lexi-Comp - Merck Manual
- RX Listing for Matulane
Intracellular chemotherapeutic agents/antineoplastic agents (L01) SPs/MIs
(M phase)Block microtubule assemblyBlock microtubule disassembly
inhibitorIIICrosslinking of DNA
(CCNS)Aziridines: Carboquone • ThioTEPA • Triaziquone • Triethylenemelamine
Photosensitizers/PDT OtherOther/ungroupedAmsacrine • Trabectedin • retinoids (Alitretinoin, Tretinoin) • Arsenic trioxide • asparagine depleters (Asparaginase/Pegaspargase) • Celecoxib • Demecolcine • Elesclomol • Elsamitrucin • Etoglucid • Lonidamine • HAMLET (human alpha-lactalbumin made lethal to tumor cells) • Lucanthone • Mitoguazone • Mitotane • Oblimersen • Omacetaxine mepesuccinate • mTOR inhibitors (Everolimus, Temsirolimus)
tumr, epon, para
Hydrazines4-PTSC • Acylhydrazine • ADH • Adjudin • Agaritine • Benmoxin • Cadralazine • Carbazide • Carbazone • Carbidopa • Carbohydrazide • Daminozide • Dihydralazine • DNPH • Endralazine • Gyromitrin • HBT • Hydralazine • Hydrazide • Hydrazine • Hydrazone • IDH • Iproclozide • Iproniazid • Isocarboxazid • Isoniazid • Mebanazine • Metfendrazine • MMH • Nialamide • Octamoxin • PEH • Phenelzine • Pheniprazine • Phenoxypropazine • Phenylhydrazine • Pimagedine • Pivalylbenzhydrazine • Procarbazine • Safrazine • SDH • Semicarbazide • Semicarbazone • SDMH • Tetrafluorohydrazine • Thiosemicarbazide • Thiosemicarbazone • UDMH
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procarbazine — noun Etymology: propyl + carbamic acid + azine Date: 1965 an antineoplastic drug C12H19N3O that is a monoamine oxidase inhibitor used in the form of its hydrochloride especially in the palliative treatment of Hodgkin s disease … New Collegiate Dictionary
procarbazine — pro·car·ba·zine (prō kärʹbə zēn) n. A potent antineoplastic drug, C12H19N3O, used primarily to treat advanced Hodgkin s disease. [propyl + carbo + azine.] * * * … Universalium
procarbazine — noun A particular drug used in chemotherapy … Wiktionary
procarbazine — pro·car·ba·zine prō kär bə .zēn, zən n an antineoplastic drug that occurs as a white to yellowish crystalline powder, is a monoamine oxidase inhibitor, and is used in the form of its hydrochloride C12H19N3O·HCl esp. in the palliative treatment of … Medical dictionary
procarbazine — pro·car·ba·zine … English syllables
procarbazine — n. a drug that inhibits growth of cancer cells by preventing cell division and is used to treat such cancers as Hodgkin s disease. It is administered by mouth; side effects may include loss of appetite, nausea, myelosuppression, and rash … The new mediacal dictionary
procarbazine — A drug that is used to treat cancer. It belongs to the family of drugs called alkylating agents … English dictionary of cancer terms
procarbazine — noun an antineoplastic drug used to treat Hodgkin s disease • Hypernyms: ↑antineoplastic, ↑antineoplastic drug, ↑cancer drug … Useful english dictionary
procarbazine hydrochloride — An antineoplastic agent. * * * pro·car·ba·zine hy·dro·chlo·ride (pro kahrґbə zēn) [USP] an alkylating agent specific for the S phase of the cell cycle used as an antineoplastic, primarily in combination with mechlorethamine, vincristine … Medical dictionary
Mustargen Oncovin Procarbazine Prednisone — MOPP is a combination chemotherapy regimen used to treat Hodgkin s disease. The acronym is derived from the component drugs of the regimen: Mustargen (also known as mechlorethamine, mustine, nitrogen mustard, or MSD) Oncovin (also known as… … Wikipedia