Dense granule

Dense granule
Latin granulum delta
Code TH H2.00.04.1.03006

Dense granules (also known as dense bodies or delta granules) are specialized secretory organelles.

Contents

In unicellular organisms

They are found in animals and in unicellular organisms including Apicomplexa protozoans.

They are also found in Entamoeba.[1]

In multicellular organisms

Components

The dense granules of human platelets contain adenosine diphosphate (ADP), adenosine triphosphate (ATP), ionized calcium which is necessary for several steps of the coagulation cascade, and serotonin.[2]

Clinical significance

A deficiency of CD63 can be associated with Hermansky-Pudlak syndrome.[3]

See also

References

  1. ^ James Joseph Marr; Timothy W. Nilsen; Richard Komuniecki (2003). Molecular medical parasitology. Academic Press. pp. 254–. ISBN 9780124733466. http://books.google.com/books?id=KjSCOT_cUXQC&pg=PA254. Retrieved 12 November 2010. 
  2. ^ Stuart H. Orkin; David G. Nathan; David Ginsburg; A. Thomas Look (2009). Nathan and Oski's hematology of infancy and childhood. Elsevier Health Sciences. pp. 1386–. ISBN 9781416034308. http://books.google.com/books?id=_9CmOIvgJm4C&pg=PA1386. Retrieved 2 November 2010. 
  3. ^ Nishibori M, Cham B, McNicol A, Shalev A, Jain N, Gerrard J (1993). "The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin.". J Clin Invest 91 (4): 1775–82. doi:10.1172/JCI116388. PMC 288158. PMID 7682577. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=288158. 

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