Oncocytoma

Oncocytoma
Classification and external resources

Micrograph of a renal oncocytoma. H&E stain.
ICD-O: M8290/0
DiseasesDB 31956
eMedicine med/1045
MeSH D018249
Gross appearance of the cut surface of a nephrectomy specimen containing a renal oncocytoma. Note the rounded contour, the mahogany colour and the central scar.

An oncocytoma is a tumor made up of oncocytes, a special kind of cells. [1] [2]

Contents

Presentation

An oncocytoma is an epithelial tumor composed of oncocytes, large eosinophilic cells having small, round, benign-appearing nuclei with large nucleoli.

Oncocytoma can arise in a number of organs.

Renal oncocytoma

Salivary gland oncocytoma

Oncocytoma of the Salivary Gland. This lesion presented as a lateral anterior neck mass. At surgery, it was found to be a soft 3.0 x 2.1 x 1.8 cm tumor of the submandibular salivary gland. The photo shows the characteristic dark color of an oncocytoma, a rare type of benign neoplasm, at the left side of the image (the normal lobulated salivary gland tissue is to the right).

The salivary gland oncocytoma is a well-circumscribed, benign neoplastic growth also called an oxyphilic adenoma. It comprises about 1% of all salivary gland tumors. The histopathology is marked by sheets of large swollen polyhedral epithelial oncocytes, which are granular acidophilic parotid cells with centrally located nuclei. The granules are created by the mitochondria.

Symptoms

Salivary gland oncocytomas are most common in ages 70-80, females, the parotid gland (85-90%), and are firm, slowly growing, painless masses of < 4 cm. They may be bilateral.

Thyroid oncocytoma

Thyroid oncocytomas can be benign (adenomas) or malignant (carcinomas). Grossly, oncocytic adenomas are encapsulated, solid nodules with a characteristic brown cut surface. The gross appearance of a minimally invasive oncocytic carcinoma is indistinguishable to that of an adenoma, while widely invasive oncocytic carcinomas are obviously invasive macroscopically and display pervasive vascular invasion with multifocal involvement of the thyroid gland. There are no reliable cytologic features which distinguish oncocytic adenomas from carcinomas and the only criteria for a diagnosis of malignancy is the identification of transcapsular and/or vascular invasion.

Symptoms

Patients with thyroid oncocytomas present with a thyroid nodule, usually with normal thyroid function. If the tumor is big or invasive, there may be other symptoms such as difficulty swallowing or talking.

See also

Additional images

References


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Look at other dictionaries:

  • oncocytoma — noun A benign tumour composed of oncocytes …   Wiktionary

  • oncocytoma — A glandular tumor composed of large cells with cytoplasm that is granular and eosinophilic because of the presence of abundant mitochondria; occurs uncommonly in the kidney, salivary glands, and endocrine glands. SYN: oxyphil adenoma. [onco + G.… …   Medical dictionary

  • renal oncocytoma — a benign neoplasm of the kidney that resembles a renal cell carcinoma but is encapsulated and not invasive; most patients are middle aged and have few overt symptoms from the tumor …   Medical dictionary

  • онкоцитома — (oncocytoma; онкоцит + ома) 1) опухоль, исходящая из онкоцитов; 2) см. Аденолимфома …   Большой медицинский словарь

  • Онкоцито́ма — (oncocytoma; Онкоцит + ома) 1) опухоль, исходящая из онкоцитов; 2) см. Аденолимфома …   Медицинская энциклопедия

  • Onkozytom — der Gl. submandibularis …   Deutsch Wikipedia

  • Warthin's tumor — Classification and external resources This Warthin s tumor presented as a parotid mass in a middle aged male, who underwent superficial parotidectomy. The tumor, at the right of the image, is well demarcated from the adjacent parotid tissue and… …   Wikipedia

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  • Kidney cancer — Classification and external resources Micrograph showing the most common type of kidney cancer (clear cell renal cell carcinoma). H E stain …   Wikipedia


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