Hemosiderosis

Infobox_Disease
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Caption = Image of a kidney viewed under a microscope. The brown areas contain hemosiderin
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Hemosiderosis (AmE) or haemosiderosis (BrE) is a form of iron overload disorder resulting in the accumulation of hemosiderin.

Types include:
* Transfusion hemosiderosis
* Idiopathic pulmonary haemosiderosis

Hemosiderin deposition in the lungs is often seen after diffuse alveolar hemorrhage, which occurs in diseases such as Goodpasture's syndrome, Wegener's granulomatosis, and idiopathic pulmonary haemosiderosis. Mitral stenosis can also lead to pulmonary hemosiderosis. Hemosiderin collects throughout the body in hemochromatosis. Hemosiderin deposition in the liver is a common feature of hemochromatosis and is the cause of liver failure in the disease. Deposition in the pancreas leads to diabetes and in the skin leads to hyperpigmentation. Hemosiderin deposition in the brain is seen after bleeds from any source, including chronic subdural hemorrhage, Cerebral arteriovenous malformations, cavernous hemangiomata. Hemosiderin collects in the skin and is slowly removed after bruising; hemosiderin may remain in some conditions such as stasis dermatitis. Hemosiderin in the kidneys have been associated with marked hemolysis and a rare blood disorder called Paroxysmal Nocturnal Hemoglobinuria.

Hemosiderin may deposit in diseases associated with iron overload. These diseases are typically diseases in which chronic blood loss requires frequent blood transfusions, such as sickle cell anemia and thalassemia.

Treatment

Treatment for hemosiderin focuses on limiting the effects of the underlying disease leading to continued deposition. In hemochromatosis, this entails frequent phlebotomy. In diseases such as Wegener's granulomatosis, immune suppression is required. Limiting blood transfusions and institution of iron chelation therapy when iron overload is detected are important when managing sickle-cell anemia and other chronic hemolytic anemias.

ee also

* Siderosis


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Look at other dictionaries:

  • hemosiderosis — depósito de hierro, generalmente en el hígado o los pulmones debido a la acumulación de hemosiderina microfotografía [véase http://www.iqb.es/diccio/h/he.htm#hemosiderosis] Diccionario ilustrado de Términos Médicos.. Alvaro Galiano. 2010.… …   Diccionario médico

  • hemosiderosis — n. (Med.) The accumulation of abnormal amounts of hemosiderin in the tisssues. Several causes have been recognized. Stedman. [PJC] …   The Collaborative International Dictionary of English

  • Hemosiderosis — Se llama hemosiderosis (del griego αἷμα sangre y σίδηρος hierro ) a la enfermedad caracterizada por el exceso de hemosiderina en los tejidos, que no produce daño orgánico pero puede evolucionar a hemocromatosis. Se produce cuando hay una… …   Wikipedia Español

  • hemosiderosis — Accumulation of hemosiderin in tissue, particularly in liver and spleen. See hemochromatosis. [hemosiderin + osis, condition] idiopathic pulmonary h. repeated sudden attacks of dyspnea and hemoptysis leading to …   Medical dictionary

  • hemosiderosis — n. condition characterized by the buildup of iron stores in the tissues of the body (especially in the liver) …   English contemporary dictionary

  • hemosiderosis — he·mo·sid·er·o·sis …   English syllables

  • hemosiderosis — noun abnormal deposit of hemosiderin; often a symptom of thalassemia or hemochromatosis • Syn: ↑haemosiderosis • Hypernyms: ↑symptom …   Useful english dictionary

  • Hemosiderosis pulmonar idiopática — Clasificación y recursos externos CIE 9 516.1 OMIM 178550 DiseasesDB …   Wikipedia Español

  • hemosiderosis idiopática — Acumulación de depósitos de hierro intracelulares en los pulmones como consecuencia de hemorragias en los pulmones. Diccionario Mosby Medicina, Enfermería y Ciencias de la Salud, Ediciones Hancourt, S.A. 1999 …   Diccionario médico

  • Transfusion hemosiderosis — Infobox Disease Name = PAGENAME Caption = DiseasesDB = ICD10 = ICD10|T|80|8|t|80 ICD9 = ICD9|999.8 ICDO = OMIM = MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = Transfusional hemosiderosis is the accumulation of iron in the liver and/or… …   Wikipedia

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