IUPAC_name = 2-(2-benzylphenoxy)-"N","N"-dimethylethanamine
C=17 | H=21 | N=1 | O=1
molecular_weight = 255.359
legal_US = OTC
Phenyltoloxamine is an
antihistaminewith sedativeand analgesiceffects. It is a member of the ethanolamineclass of antihistaminergicagents and a potent anticholinergic, with 55 per cent of the anti-muscarinic potency of atropine.
Phenyltoloxamine is widely used in preparations as an enhancing
agentfor some analgesics and antitussives ( acetaminophen, codeine, hydrocodone). It is widely used in certain parts of the world as cough suppressantusually with codeine.
It is also used to discourage
abusein certain opiateanalgesics due its unpleasant side effects at high doses. While therapeutic doses of phenyltoloxamine can generate mild euphoria as can many of its chemical relatives, much higher doses have a side effect profile similar to that of atropine, which is also used in this fashion for tablets of diphenoxylateand morphinefor oral administration.
adverse effectsare those associated with most anticholinergics, effects are more pronounced in children and the elderly.
Phenyltoloxamine is available in most countries, though it is rare in several
western countriesit remains widely used around the world, particularly in the developing world.
It is not a
controlled substance; however some preparations contain opiates such as codeine or hydrocodone and are controlled, when used in preparations with acetaminophenis generally over the counter.
Phenyltoloxamine is sold under wide variety of preparations, brand names and dosages around the world:
*Ed-Flex, Dologesic, Duraxin, Flextra-650, Novagesic, Phenylgesic - North America
*Codipront - Europe/South America
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