IUPAC_name = Unable to be assigned

CAS_number =
CAS_supplemental =
ATC_prefix =
ATC_suffix =
ATC_supplemental =
PubChem =
DrugBank =
chemical_formula =
C=4318 | H=6788 | N=1164 | O=1304 | S=32
molecular_weight =
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
excretion =
pregnancy_AU =
pregnancy_US =
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration =

Aflibercept is a fusion protein under development for the treatment of cancer.

It functions as an inhibitor of vascular endothelial growth factor.cite journal |author=Fraser HM, Wilson H, Silvestri A, Morris KD, Wiegand SJ |title=The Role of Vascular Endothelial Growth Factor and Estradiol in the Regulation of Endometrial Angiogenesis and Cell Proliferation in the Marmoset |journal=Endocrinology |volume= |issue= |pages= |year=2008 |month=May |pmid=18499749 |doi=10.1210/en.2008-0325 |url=] cite journal |author=Duncan WC, van den Driesche S, Fraser HM |title=Inhibition of Vascular Endothelial Growth Factor in the Primate Ovary Up-Regulates Hypoxia-Inducible Factor-1{alpha} in the Follicle and Corpus Luteum |journal=Endocrinology |volume=149 |issue=7 |pages=3313–20 |year=2008 |month=July |pmid=18388198 |doi=10.1210/en.2007-1649 |url=]

Aflibercept is being co-developed by Sanofi-Aventis and Regeneron Pharmaceuticals. As of 2008, it is currently in phase III clinical trials.


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • aflibercept — noun A fusion protein under development for the treatment of cancer …   Wiktionary

  • Macular degeneration — Classification and external resources Picture of the fundus showing intermediate age related macular degeneration. ICD 10 …   Wikipedia

  • Regeneron — Infobox Company company name = Regeneron Pharmaceuticals, Inc. company company type = Public (NASDAQ:REGN)(virt x:REGN) foundation = 1988 location = Tarrytown, New York, USA (Headquarters) key people = Leonard Schleifer (CEO), George Yancopoulos …   Wikipedia

  • Chemotherapy — A woman being treated with docetaxel chemotherapy for breast cancer. Cold mittens and wine coolers are placed on her hands and feet to reduce harm to her nails. Chemotherapy (sometimes cancer chemotherapy) is the treatment of cancer with an… …   Wikipedia

  • Thalidomide — This article is about the drug. For the musical about a person with thalidomide disability, see Thalidomide!! A Musical. Thalidomide Systematic (IUPAC) name (RS) 2 (2,6 dioxopiperidin 3 yl) 1H isoind …   Wikipedia

  • Ciclosporin — Cyclosporin redirects here. For other types of cyclosporin, see Cyclosporins. Ciclosporin Systematic ( …   Wikipedia

  • Methotrexate — Amethopterin redirects here. Not to be confused with aminopterin. Methotrexate Systematic ( …   Wikipedia

  • Everolimus — Systematic (IUPAC) name dihydroxy 12 [(2R) 1 [(1S,3R,4R) 4 (2 hydroxyethoxy) 3 methoxycyclohexyl]propan 2 yl] 19,30 dimethoxy 15,17,21,23,29,35 hexamethyl 11,36 dioxa 4 azatricyclo[,9]hexatriaconta 16,24,26,28 tetraene 2,3,10,14,20… …   Wikipedia

  • Mycophenolic acid — Systematic (IUPAC) name (4E) ​6 ​(4 ​Hydroxy ​6 ​methoxy ​7 ​methyl ​3 ​oxo ​1,​3 ​dihydro ​2 ​benzofuran ​5 ​yl) ​4 ​methylhex ​4 ​enoic acid Clinical data …   Wikipedia

  • Daclizumab — ? Monoclonal antibody Type Whole antibody Source Humanized (from mouse) Target CD25 Clinical data Trade names Zenapax AHFS/ …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.