Aflibercept


Aflibercept

Drugbox
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C=4318 | H=6788 | N=1164 | O=1304 | S=32
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Aflibercept is a fusion protein under development for the treatment of cancer.

It functions as an inhibitor of vascular endothelial growth factor.cite journal |author=Fraser HM, Wilson H, Silvestri A, Morris KD, Wiegand SJ |title=The Role of Vascular Endothelial Growth Factor and Estradiol in the Regulation of Endometrial Angiogenesis and Cell Proliferation in the Marmoset |journal=Endocrinology |volume= |issue= |pages= |year=2008 |month=May |pmid=18499749 |doi=10.1210/en.2008-0325 |url=http://endo.endojournals.org/cgi/pmidlookup?view=long&pmid=18499749] cite journal |author=Duncan WC, van den Driesche S, Fraser HM |title=Inhibition of Vascular Endothelial Growth Factor in the Primate Ovary Up-Regulates Hypoxia-Inducible Factor-1{alpha} in the Follicle and Corpus Luteum |journal=Endocrinology |volume=149 |issue=7 |pages=3313–20 |year=2008 |month=July |pmid=18388198 |doi=10.1210/en.2007-1649 |url=http://endo.endojournals.org/cgi/pmidlookup?view=long&pmid=18388198]

Aflibercept is being co-developed by Sanofi-Aventis and Regeneron Pharmaceuticals. As of 2008, it is currently in phase III clinical trials.

References


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