Waf1


Waf1
(= p21; cip1)
Inhibitor (21 kD) of cdk activity; found in a complex with cyclin D, cdk4 and PCNA. Can bind to and inhibit all members of the cdk family though affinity varies. Expression regulated by p53 tumour suppressor. Also found in active cyclin/cdk complexes - multiple copies of Waf1 may be necessary to produce inhibition.

Dictionary of molecular biology. 2004.

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