- tumour suppressor
(= antioncogene; cancer susceptibility gene)A gene that encodes a product that normally negatively regulates the cell cycle, and that must be mutated or otherwise inactivated before a cell can proceed to rapid division. Examples: p53, RB (retinoblastoma), WT-1 (Wilms&’ tumour), DCC (deleted in colonic carcinoma), NF-1 (neurofibrosarcoma) and APC (adenomatous polyposis coli).
Dictionary of molecular biology. 2004.
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tumour suppressor gene — ▪ pathology also called Anti oncogene, any of a class of genes that are normally involved in regulating cell growth but that may become cancer causing when damaged. Tumour suppressor genes encode for proteins that are involved in… … Universalium
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ARF tumor suppressor — The ARF tumor suppressor is a protein that is transcribed from an alternate reading frame of the INK4a/ARF locus (CDKN2A). ARF is induced in response to sustained mitogenic stimulation, such as aberrant growth signaling from MYC and Ras… … Wikipedia
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Rb — Tumour suppressor gene encoding a nuclear protein that, if inactivated, enormously raises the chances of development of cancer, classically retinoblastoma, but also other sarcomas and carcinomas … Dictionary of molecular biology
Deleted in Colorectal Cancer — Deleted in colorectal carcinoma Rendering based on PDB 2ED7 … Wikipedia
p53 — For the band and album of the same name, see P53 (band) and P53 (album). Tumor protein p53 PDB rendering based on 1TUP … Wikipedia
genetic disease, human — Introduction any of the diseases and disorders that are caused by mutations in one or more genes (gene). With the increasing ability to control infectious and nutritional diseases in developed countries, there has come the realization … Universalium