trinucleotide repeat


trinucleotide repeat
Repetitive part of a genome that may form part of the coding sequence of a gene. The length of such repeats is frequently polymorphic, and unstably amplified repeats appear to be the major cause of such genetic diseases as Huntington\'s chorea, fragile X syndrome, spinobulbar muscular atrophy and myotonic dystrophy.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • trinucleotide repeat — Tandem repeats of three nucleotides that are present in many genes. Commonly trinucleotide repeats have undergone variable expansion in copy number, forming the basis of microsatellite markers, and occasionally resulting in the formation of… …   Glossary of Biotechnology

  • trinucleotide repeat — triplet repeat an unstable DNA sequence of three nucleotides, occurring in some human genes and normally repeated in tandem 5 to 50 times; expansion above that number has been linked to certain genetic disorders. The triplet sequences always… …   Medical dictionary

  • Trinucleotide repeat disorder — Trinucleotide repeat disorders (also known as trinucleotide repeat expansion disorders, triplet repeat expansion disorders or codon reiteration disorders) are a set of genetic disorders caused by trinucleotide repeat expansion, a kind of mutation …   Wikipedia

  • Trinucleotide repeat expansion — Trinucleotide repeat expansion= Trinucleotide repeat expansion, also known as triplet repeat expansion, is the DNA mutation responsible for causing any type of disorder categorized as a trinucleotide repeat disorder. These are labelled in… …   Wikipedia

  • trinucleotide repeat disorders — triplet repeat disorders disorders caused by unstable, dynamic mutations that result in expansion of triplet repeats within the affected gene, leading to abnormalities in gene expression and function. The disorders differ significantly in such… …   Medical dictionary

  • trinucleotide repeat disorder — noun Any of a group of disorders caused by stretches of DNA that contain a sequence of three nucleotides repeated many times …   Wiktionary

  • Tandem repeat — Tandem repeats occur in DNA when a pattern of two or more nucleotides is repeated and the repetitions are directly adjacent to each other. [1] Contents 1 Example 2 Terminology 3 Uses …   Wikipedia

  • Direct repeat — Direct repeats are a type of genetic sequence that consists of two or more repeats of a specific sequence.[1] Direct repeats are nucleotide sequences present in multiple copies in the genome. There are several types of repeated sequences.… …   Wikipedia

  • Variable number tandem repeat — A Variable Number Tandem Repeats (or VNTR) is a location in a genome where a short nucleotide sequence is organized as a tandem repeat. These can be found on many chromosomes, and often show variations in length between individuals. Each variant… …   Wikipedia

  • TNRC6A — Trinucleotide repeat containing 6A, also known as TNRC6A, is a human gene.cite web | title = Entrez Gene: TNRC6A trinucleotide repeat containing 6A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=27327|… …   Wikipedia


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