Drosophila gene required for dorsoventral polarity determination. Protein (124 kD) is a transmembrane receptor with leucine-rich repeat. Interacts downstream with pelle and tube and defines dorsoventral polarity in the embryo. Toll, which is present over the entire surface of the embryo, is activated ventrally by interaction with a spatially restricted, extracellular ligand.
Dictionary of molecular biology. 2004.