- T-helper cells
(= TH cells; Th1; Th2)There are now recognized to be two subclasses of CD4 positive T-helper cells, Th1 and Th2. Th1 cells produce IL-2, IFN g and TNF a and do not produce IL-4, IL-5 and IL-10. They are associated with cell-mediated immunity. Selective activation of Th1 cells is promoted by IFN g and IL-12 and inhibited by IL-4 and IL-10, the products of Th2 cells. Th2 cells are involved with the humoral immune response, produce IL-4, IL-5 and IL-10 and promote antibody production; IL-4 is essential for growth and differentiation of Th2 cells. There is cross-inhibition between the two classes, if one subclass is activated it will inhibit the activity of the other so that the response is polarized.
Dictionary of molecular biology. 2004.
Look at other dictionaries:
helper cells — helper T cells differentiated T lymphocytes whose cooperation (help) is required for the production of antibody against most (T dependent) antigens. Activation of B lymphocytes (B cells) requires recognition of the antigenic determinant against… … Medical dictionary
helper cells — helper cells. = TH lymphocytes (см.). (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) … Молекулярная биология и генетика. Толковый словарь.
helper cells — helper cells. См. Т хелперы. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) … Молекулярная биология и генетика. Толковый словарь.
T-helper cells — helper c s … Medical dictionary
Helper cell — A type of T cell that participates in the immune response by recognizing foreign antigens and secreting substances called cytokines that activate T and B cells. Helper cells fall into two main classes: those that activate other T cells to achieve … Medical dictionary
Helper/suppressor ratio — The T Lymphocyte Helper/Suppressor Profile (Helper/Suppressor ratio, T4:T8 ratio, CD4:CD8 ratio) is a basic laboratory test in which the percentage of CD3 positive lymphocytes in the blood positive for CD4 (T helper cells) and CD8 (a class of… … Wikipedia
helper T-cell — See T helper cells … Dictionary of molecular biology
helper T cell — n. a type of T cell that helps coordinate the immune response, especially by activating B cells: the AIDS virus targets and destroys these T cells … English World dictionary
helper T lymphocytes — helper T cells … Medical dictionary
helper T cell — noun T cell with CD4 receptor that recognizes antigens on the surface of a virus infected cell and secretes lymphokines that stimulate B cells and killer T cells; helper T cells are infected and killed by the AIDS virus • Syn: ↑helper cell, ↑CD4… … Useful english dictionary