syndecan


syndecan
An integral membrane proteoglycan (250-300 kD) associated largely with epithelial cells. The core protein of 294 amino acids has an extracellular domain of 235 amino acids and a single transmembrane domain of 25 amino acids. The extracellular domain has up to three heparan sulphate and two chondroitin or dermatan sulphate chains plus an N-linked oligosaccharide. The heparan sulphate chains bind to several proteins of the extracellular matrix, including collagens, fibronectin and tenascin. The cytoplasmic domain is thought to interact with actin filaments. Its name is derived from the Greek syndein, to bind together. Ligation of N-syndecan (syndecan-3) by heparin-binding growth-associated molecule increases phosphorylation of c-src and cortactin, and N-syndecan may act as a neurite outgrowth receptor.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Syndecan 1 — is a proteoglycan. PBB Summary section title = summary text = The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell… …   Wikipedia

  • Syndecan — One of a family of core proteins with sugars attached to the cell surfaces that control or influence tissue repair, metabolism, the formation of tumors and the development of immune responses. The name is derived from the Greek syndein, to bind… …   Medical dictionary

  • syndecan — noun Any of a class of single transmembrane domain proteins thought to act as coreceptors, especially for G protein coupled receptors …   Wiktionary

  • SDC3 — Syndecan 3, also known as SDC3, is a human gene.cite web | title = Entrez Gene: SDC3 syndecan 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=9672| accessdate = ] PBB Summary section title = summary text …   Wikipedia

  • SDC2 — Syndecan 2, also known as SDC2, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The… …   Wikipedia

  • SDC4 — Syndecan 4, also known as SDC4, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The… …   Wikipedia

  • SDCBP — Syndecan binding protein (syntenin), also known as SDCBP, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene was initially identified as a molecule linking syndecan mediated signaling to the cytoskeleton …   Wikipedia

  • SDCBP2 — Syndecan binding protein (syntenin) 2, also known as SDCBP2, is a human gene.cite web | title = Entrez Gene: SDCBP2 syndecan binding protein (syntenin) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • Sindecán-4 — Este artículo o sección tiene un estilo difícil de entender para lectores que no son expertos en el tema. Si puedes, por favor edítalo y contribuye a hacerlo más accesible para el público general, sin eliminar los detalles técnicos que interesan… …   Wikipedia Español

  • Lacritin — Lacritin, also known as LACRT, is a protein which in humans is encoded by the LACRT gene.cite web | title = Entrez Gene: LACRT lacritin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=90070| accessdate = ]… …   Wikipedia


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