- src family
Family of protein tyrosine kinases of which src was the first example. Includes Fyn, Yes, Fgr, Lyn, Hck, Lck, Blk and Yrk. All cells studied so far have one at least of these kinases which act in cellular control. Family members all have characteristic src-homology (SH) domain structure, a kinase domain (SH1), SH2 and SH3 domains, and a domain (SH4) which has myristoylation and membrane-localisation sites. Inter-domain interactions, themselves regulated by phosphorylation (see Csk), regulate the activity of the kinase.
Dictionary of molecular biology. 2004.
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