somatic recombination


somatic recombination
One of the mechanisms used to generate diversity in antibody production is to rearrange the DNA in B-lymphocytes during their differentiation, a process that involves cutting and splicing the immunoglobulin genes. Somatic recombination via homologous crossing-over occurs at a low frequency in Aspergillus, Drosophila and Saccharomyces and in mammalian cells in culture. It may be detected through the production of homozygous patches or sectors after mitosis of cells heterozygous for suitable marker genes.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • somatic recombination — somatic recombination. = mitotic recombination (см.). (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • somatic recombination — somatic recombination. См. соматическая рекомбинация. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • somatic recombination — the rearrangement of genetic material by bringing together a set of inherited, initially separated, DNA sequences by deletion of the intervening DNA; in immature B and T lymphocytes, it is the method by which the variety of genes encoding the… …   Medical dictionary

  • Somatic hypermutation — (or SHM) is a mechanism inside cells that is part of the way the immune system adapts to the new foreign elements which confront it (for example, microbes). SHM diversifies the receptors that the immune system uses to recognize foreign elements… …   Wikipedia

  • Somatic evolution in cancer — Somatic evolution is the accumulation of mutations in the cells of a body (the soma) during a lifetime, and the effects of those mutations on the fitness of those cells. Somatic evolution is important in the process of aging as well as the… …   Wikipedia

  • Recombination activating gene — protein Name=recombination activating gene 1 caption= width= HGNCid=9831 Symbol=RAG1 AltSymbols= EntrezGene=5896 OMIM=179615 RefSeq=NM 000448 UniProt=P15918 PDB= ECnumber= Chromosome=11 Arm=p Band=13 LocusSupplementaryData=protein… …   Wikipedia

  • Recombination — The trading of fragments of genetic material between chromosomes before the egg and sperm cells are created. Key features of recombination include the point to point association of paired chromosomes (synapsis) followed by the visible exchange of …   Medical dictionary

  • V(D)J recombination — V(D)J recombination, also known as somatic recombination, is a mechanism of genetic recombination in the early stages of immunoglobulin (Ig) and T cell receptors (TCR) production of the immune system. V(D)J recombination nearly randomly combines… …   Wikipedia

  • mitotic recombination — Somatic crossing over. Crossing over can occur between homologous chromosomes during mitosis, but is very rare because the chromosomes do not normally pair. When it occurs it can lead to new combinations of previously linked genes. Although… …   Dictionary of molecular biology

  • Homologous recombination — Figure 1. During meiosis, homologous recombination can produce new combinations of genes as shown here between similar but not identical copies of human chromosome 1. Homologous recombination is a type of genetic recombination in which nucleotide …   Wikipedia


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