signal sequence


signal sequence
A peptide present on proteins that are destined either to be secreted or to be membrane components. It is usually at the N-terminus and normally absent from the mature protein. Normally refers to the sequence (ca 20 amino acids) that interacts with signal recognition particle and directs the ribosome to the endoplasmic reticulum where co-translational insertion takes place. Could also refer to sequences that direct post-translational uptake by organelles. Signal peptides are highly hydrophobic but with some positively charged residues. The signal sequence is normally removed from the growing peptide chain by signal peptidase, a specific protease located on the cisternal face of the endoplasmic reticulum. See signal recognition particle.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

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  • signal sequence — signal sequence. = leader peptide sequence (см.). (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • signal sequence — signal sequence. См. сигнальная последовательность. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

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  • signal peptide — noun A short N terminal peptide sequence involved in the passage of a protein across a membrane (also signal sequence) • • • Main Entry: ↑signal …   Useful english dictionary

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  • Signal transduction — In biology, signal transduction refers to any process by which a cell converts one kind of signal or stimulus into another. Most processes of signal transduction involve ordered sequences of biochemical reactions inside the cell, which are… …   Wikipedia


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