- serum amyloid
In secondary amyloidosis the fibrils deposited in tissues are unrelated to immunoglobulin light chains (in contrast to the situation in primary amyloidosis) and are made of amyloid A protein (AA protein). This is derived from serum amyloid A (SAA) that is the apolipoprotein of a high-density lipoprotein and an acute phase protein. Partial proteolysis converts SAA into the beta pleated sheet configuration of the amyloid fibrils. Amyloid P protein is also found as a minor component of the fibrils (in both primary and secondary amyloidosis) and is derived from serum amyloid P that has similarity to C-reactive protein. The physiological role remains obscure.
Dictionary of molecular biology. 2004.
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Serum amyloid A — protein Name = Human Serum amyloid A1 caption = width = HGNCid = 10513 Symbol = SAA1 AltSymbols = EntrezGene = 6288 OMIM = 104750 RefSeq = NM 199161 UniProt = P02735 PDB = ECnumber = Chromosome = 11 Arm = p Band = 15.1 LocusSupplementaryData =… … Wikipedia
Serum amyloid P component — Amyloid P component, serum (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called amyloid .cite journal | author = Cathcart… … Wikipedia
serum amyloid P-component — Precursor of amyloid component P, found in basement membrane. Member of the pentraxin family. See serum amyloid … Dictionary of molecular biology
serum amyloid A protein — a high molecular weight protein synthesized in the liver; it is an acute phase protein and circulates in association with a subclass of HDL lipoproteins. It is the precursor to AA amyloid and accumulates in inflammation. Called also SAA p … Medical dictionary
Amyloid — Amyloids are insoluble fibrous protein aggregates sharing specific structural traits. Abnormal accumulation of amyloid in organs may lead to amyloidosis, and may play a role in various other neurodegenerative diseases. Definition controversyThe… … Wikipedia
amyloid — Glycoprotein deposited extracellularly in tissues in amyloidosis. The glycoprotein may either derive from light chain of immunoglobulin (AIO (amyloid of immune origin): 5 18 kD glycoprotein; product of a single clone of plasma cells, the N… … Dictionary of molecular biology
amyloid A — AA amyloid a pathological fibrillar low molecular weight protein formed by cleavage of serum amyloid A (SAA) protein. It is deposited in the tissues secondary to chronic inflammatory conditions; see AA amyloidosis, under amyloidosis … Medical dictionary
SAA protein — serum amyloid A p … Medical dictionary
SAA2 — Serum amyloid A2, also known as SAA2, is a human gene. [cite web | title = Entrez Gene: SAA2 Serum amyloid A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=6289| accessdate = ] PBB Summary section title … Wikipedia
SAA1 — Serum amyloid A1, also known as SAA1, is a human gene.cite web | title = Entrez Gene: SAA1 serum amyloid A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=6288| accessdate = ] PBB Summary section title =… … Wikipedia