- serine protease
One of a group of endoproteases from both animal and bacterial sources that share a common reaction mechanism based on formation of an acyl-enzyme intermediate on a specific active serine residue. Serine proteases are all irreversibly inactivated by a series of organophosphorus esters, such as di-isopropylfluorophosphate (DFP) and by naturally-occurring inhibitors (serpins). Examples are trypsin, chymotrypsin, and the bacterial enzyme subtilisin.
Dictionary of molecular biology. 2004.
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