senile plaque


senile plaque
Characteristic feature of the brains of Alzheimer\'s disease patients and aged monkeys, consisting of a core of amyloid fibrils surrounded by dystrophic neurites. The principal component of amyloid fibrils in senile plaques is B/A4, a peptide of about 4 kD that is derived from the larger amyloid precursor protein (APP). The B/A4 sequence is located near the C-terminus of APP.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • senile plaque — n PLAQUE (1d) …   Medical dictionary

  • senile plaque — …   Useful english dictionary

  • Plaque — (1) An semi hardened accumulation of substances from fluids that bathe an area. Examples include dental plaque and cholesterol plaque. Minerals form dental plaque around the teeth as a result of bacterial action on food particles. Dental plaque… …   Medical dictionary

  • Senile Plaques — (Silberimprägnation) Senile Plaques (syn. neuritische Plaques, senile Drusen, Hirndrusen) sind extrazelluläre Ablagerungen von Beta Amyloid in der grauen Hirnsubstanz. Die Ablagerungen sind vergesellschaftet mit degenerativen nervalen Strukturen… …   Deutsch Wikipedia

  • Plaque — or placque may refer to: * Commemorative plaque, a flat ornamental plate or tablet fixed to a wall, used to mark a significant event, person, etc. * Memorial plaque, issued to next of kin of dead British military personnel after WWI * Plaque, a… …   Wikipedia

  • Plaque — (frz. plaque [plak], „Platte; Fleck; Schild“) steht für: Zahnbelag, ein Biofilm auf den Zähnen Eine krankhafte Ablagerungen an den Blutgefäßwänden, siehe Arteriosklerose Senile Plaques, eine Ablagerung im Gehirn bei der Alzheimerschen Erkrankung… …   Deutsch Wikipedia

  • Senile plaques — Amyloid beta immunostaining showing senile plaques. Senile plaques (syn. neuritic plaques, senile druse, braindruse) are extracellular deposits of amyloid in the gray matter of the brain. The deposits are associated with degenerative neural… …   Wikipedia

  • Neurofibrillary tangle — Microscopy image of a neurofibrillary tangle, conformed by hyperphosphorylated tau protein Neurofibrillary Tangles (NFTs) are aggregates of hyperphosphorylated tau protein that are most commonly known as a primary marker of Alzheimer s Disease.… …   Wikipedia

  • Aubrey de Grey — In Los Angeles, California, 2008 Born 20 April 1963 (1963 04 20) (age 48) London, England Residence …   Wikipedia

  • SP — Abbreviation for sacroposterior position. * * * sacroposterior; sacrum to pubis; salivary progesterone; schizotypal personality; secretory piece; semi private [room]; senile plaque; sepiapterin; septal pore; septum pellucidum; sequence processor… …   Medical dictionary


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