senescent cell antigen


senescent cell antigen
An antigen (62 kD) that appears on the surface of senescent erythrocytes and is immunologically cross-reactive with isolated band III. Seems to be recognized by an autoantibody, and the immunoglobulin-coated erythrocyte is then removed from circulation by cells such as Kuppfer cells of the liver that have Fc receptors. Intracellular cleavage of intact band III by a calcium-activated protease, calpain, may reveal the antigen in situ.

Dictionary of molecular biology. 2004.

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