RTX family of toxins

RTX family of toxins
A group of related cytolysins and cytotoxins produced by Gram negative bacteria including E. coli, Proteus vulgaris (hemolysin), Pasteurella haemolytica (leukotoxin) and Bordetella pertussis (adenylate cyclase-hemolysin). Characteristically contain a repeat domain (hence the designation, repeats in toxins) with glycine and aspartate-rich motifs repeated within the domain. All are produced in inactive pro-form that must be post-translationally modified to generate an active toxin and are calcium-dependent pore-forming toxins. See Escherichia coli hemolysin.

Dictionary of molecular biology. 2004.

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