platelet-derived growth factor


platelet-derived growth factor
(= PDGF)
The major mitogen in serum for growth in culture of cells of connective tissue origin. It consists of 2 different but homologous polypeptides A and B (platelet-derived growth factor30,000 D) linked by disulphide bonds. Believed to play a role in wound healing. The B chain is almost identical in sequence to p28sis, the transforming protein of simian sarcoma virus, that can transform only those cells that express receptors for PDGF, suggesting that transformation is caused by autocrine stimulation. Receptor is a tyrosine kinase.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Platelet-derived growth factor — (PDGF) Identifiers Symbol PDGF Pfam PF00341 InterPro …   Wikipedia

  • Platelet-Derived Growth Factor A — Platelet Derived Growth Factor, Untereinheit A Masse/Länge Primärstruktur 125 Aminosäuren …   Deutsch Wikipedia

  • platelet-derived growth factor — n a mitogenic growth factor that is found esp. in platelets, consists of two polypeptide chains linked by bonds containing two sulfur atoms each, stimulates cell proliferation (as in connective tissue, smooth muscle, and glia), and plays a role… …   Medical dictionary

  • platelet-derived growth factor — platelet derived growth factor. См. фактор роста тромбоцитов. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Platelet Derived Growth Factor — Der Name Platelet derived growth factor (PDGF) steht für eine Familie von vier Wachstumsfaktoren (PDGF A, PDGF B, PDGF C und PDGF D), die alle als Mitogen auf Zellen wirken, die ihren Ursprung im embryonalen Bindegewebe haben. Sie werden bei… …   Deutsch Wikipedia

  • platelet-derived growth factor — PDGF; see growth factor …   The new mediacal dictionary

  • platelet-derived growth factor — see growth factor …   Medical dictionary

  • platelet-derived growth factor — ˈ ̷ ̷  ̷ ̷  ̷ ̷ ˌ ̷ ̷ noun : a mitogenic growth factor that is found especially in platelets, consists of two polypeptide chains linked by bonds containing two sulfur atoms each, stimulates cell proliferation (as in connective tissue, smooth… …   Useful english dictionary

  • Platelet-derived Growth Factor — Plate|let de|rived Growth Fac|tor [ pleɪtlət dɪraɪft grəʊo fæktə[r]; engl. = Plättchenwachstumsfaktor], der; s: svw. ↑ PDGF …   Universal-Lexikon

  • Platelet-derived growth factor receptor — platelet derived growth factor receptor, alpha polypeptide Identifiers Symbol PDGFRA Entrez 5156 HUGO …   Wikipedia


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