(= LTA4, LTB4, LTC4, LTD4, LTE4)A family of hydroxyeicosatetraenoic (HETE) acid derivatives. LTA4 and LTB4 are modified lipids; leukotrienes C, D and E have the lipid conjugated to glutathione (LTC4) or cysteine (LTD 4, LTE4) to form the peptidyl leukotrienes. A mixture of the latter (LTC4, LTD4, LTE4) constitute SRS-A, the slow reacting substance of anaphylaxis, that has potent bronchoconstrictive effects. LTB4 is a potent neutrophil chemotactic factor.
Dictionary of molecular biology. 2004.
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