(= hypoxanthine-guanine phosphoribosyl transferase)Enzyme that catalyses the first step in the pathway for salvage of the purines hypoxanthine and guanine. The phosphoribosyl moiety is transferred from an activated precursor, 5-phosphoribosyl 1-pyrophosphate. Since animal cells can synthesize purines de novo, HGPRT-mutants can be selected by their resistance to toxic purine analogues. A genetic lesion in HGPRT in humans underlies the Lesch-Nyhan syndrome. See HAT medium.
Dictionary of molecular biology. 2004.
Look at other dictionaries:
HGPRT — Abbreviation for hypoxanthine guanine phosphoribosyltransferase. * * * hypoxanthine guanine phosphoribosyl transferase * * * hypoxanthine guanine phosphoribosyltransferase, a common name for hypoxanthine phosphoribosyltransferase (HPRT) … Medical dictionary
HGPRT — Hypoxantine guanine phosphorybosil transferase (Hipoxantina guaninafosforribosil transferasa) … Diccionario de siglas médicas y otras abreviaturas
HGPRT — • hypoxanthine guanine phosphoribosyl transferase … Dictionary of medical acronyms & abbreviations
HGPRT — biomed. abbr. Hypoxanthine Guanine Phosphoribosyl Transferase … United dictionary of abbreviations and acronyms
hypoxanthine guanine phosphoribosyl transferase — (= HGPRT) See HGPRT … Dictionary of molecular biology
Lesch–Nyhan syndrome — Lesch Nyhan syndrome Classification and external resources ICD 10 E79.1 ICD 9 277.2 … Wikipedia
Monoclonal antibodies — A general representation of the methods used to produce monoclonal antibodies. Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a unique… … Wikipedia
Nucleotide salvage — A salvage pathway is a pathway in which nucleotides (purine and pyrimidine) are synthesized from intermediates in the degradative pathway for nucleotides. Salvage pathways are used to recover bases and nucleosides that are formed during… … Wikipedia
HAT medium — (Hypoxanthine Aminopterin Thymidine medium) is a selection medium for mammalian cell culture, which relies on the combination of aminopterin, a drug that acts as a folate metabolism inhibitor by inhibiting dihydrofolate reductase, with… … Wikipedia
Lesch-Nyhan syndrome — Infobox Disease Name = Lesch Nyhan syndrome Caption = Philip Baker, an adult with Lesch Nyhan Syndrome. Visible in this picture are the restraints on Philip s chair that he must use to control his involuntary movement. ICD10 = ICD10|E|79|1|e|70… … Wikipedia