(= hypoxanthine-guanine phosphoribosyl transferase)
Enzyme that catalyses the first step in the pathway for salvage of the purines hypoxanthine and guanine. The phosphoribosyl moiety is transferred from an activated precursor, 5-phosphoribosyl 1-pyrophosphate. Since animal cells can synthesize purines de novo, HGPRT-mutants can be selected by their resistance to toxic purine analogues. A genetic lesion in HGPRT in humans underlies the Lesch-Nyhan syndrome. See HAT medium.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

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  • HGPRT — • hypoxanthine guanine phosphoribosyl transferase …   Dictionary of medical acronyms & abbreviations

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