(= polymorphic epithelial mucin, PEM; epithelial membrane antigen, EMA)Heavily glycosylated membrane glycoprotein. Encoded by the MUC- 1 gene; has a molecular weight of around 300 kD, more than half of which is O -linked glycan. There is a 69 residue cytoplasmic domain and the extracellular domain may extend hundreds of nanometres beyond the plasma membrane; the increased expression in carcinoma cells may reduce the adhesion and mask antigenic properties of the cells. Similar functions are ascribed to ASGP, epiglycanin and leukosialin.
Dictionary of molecular biology. 2004.
Look at other dictionaries:
episialin — noun An epithelial sialomucin … Wiktionary
MUC1 — Mucin 1, cell surface associated SEA Domain of MUC1. PDB rendering based on 2acm … Wikipedia
OSGEP — O sialoglycoprotein endopeptidase Identifiers Symbols OSGEP; FLJ20411; GCPL1; KAE1; OSGEP1; PRSMG1 External IDs … Wikipedia
ASGP — Membrane associated mucin present on rat mammary carcinoma cells. ASGP 1 and ASGP 2 are generated from a single precursor; ASGP 2 acts as a membrane anchor for ASGP 1. Though ASGP is thought to have similar functions, has no sequence homology… … Dictionary of molecular biology
1EMA — (1) Epithelial membrane antigen; see episialin. (2) E2F binding site modulating activity: transcriptional repressor (272 residues, 34 kD) that has some similarity with E2F but lacks the activation domain at the carboxy terminus … Dictionary of molecular biology
epithelial membrane antigen — See episialin … Dictionary of molecular biology
leukosialin — (= CD43; sialophorin) Widely distributed membrane associated mucin, the major sialoglycoprotein of thymocytes and mature T cells. Transmembrane protein with extensive O linked glycosylation (75 85 oligosaccharides on the 239 residue extracellular … Dictionary of molecular biology
MUC-1 — See episialin … Dictionary of molecular biology
PEM — (= polymorphic epithelial mucin) See episialin … Dictionary of molecular biology
polymorphic epithelial mucin — See episialin … Dictionary of molecular biology