- DNA methylation
Process by which methyl groups are added to certain nucleotides in genomic DNA. This affects gene expression, as methylated DNA is not easily transcribed. The degree of methylation is passed on to daughter strands at mitosis by maintenance DNA methylases. Accordingly, DNA methylation is thought to play an important developmental role in sequentially restricting the transcribable genes available to distinct cell lineages. In bacteria, methylation plays an important role in the restriction systems, as restriction enzymes cannot cut sequences with certain specific methylations.
Dictionary of molecular biology. 2004.
Look at other dictionaries:
DNA methylation — n the enzymatically controlled methylation of a nucleotide base (as cytosine in eukaryotes) in a molecule of DNA that plays a role in suppressing gene expression * * * the postsynthetic addition of methyl groups to specific sites on DNA… … Medical dictionary
DNA methylation — Illustration of a DNA molecule that is methylated at the two center cytosines. DNA methylation plays an important role for epigenetic gene regulation in development and disease. DNA methylation is a biochemical process that is important for… … Wikipedia
DNA methyltransferase — n a methyltransferase that promotes the covalent addition of a methyl group to a specific nucleotide base in a molecule of DNA * * * DNA meth·yl·trans·fer·ase (meth″əl transґfər ās) any of a group of enzymes that catalyze the … Medical dictionary
Methylation specific oligonucleotide microarray — was developed as a technique to map methylation changes in DNA in cancer. This technique was developed by Professor Tim Hui Ming Huang and was published in journal Genome Research on 2002 (Gitan et al., 2002). The method utilizes bisulfite… … Wikipedia
Methylation — In the chemical sciences, methylation denotes the addition of a methyl group to a substrate or the substitution of an atom or group by a methyl group. Methylation is a form of alkylation with, to be specific, a methyl group, rather than a larger… … Wikipedia
DNA methyltransferase — N 6 DNA Methylase crystal structure of type i restriction enzyme ecoki m protein (ec 18.104.22.168) (m.ecoki) Identifiers Symbol N6 Mtase Pfam … Wikipedia
DNA — For a non technical introduction to the topic, see Introduction to genetics. For other uses, see DNA (disambiguation). The structure of the DNA double helix. The atoms in the structure are colour coded by element and the detailed structure of two … Wikipedia
DNA-Methylierung — Übergeordnet epigenetische Regulation der Genexpression Methylierung von Makromolekülen DNA Modifikation … Deutsch Wikipedia
Méthylation — La méthylation est l attache ou la substitution d un groupement méthyle sur un substrat. La déméthylation est au contraire, la suppression d un groupe méthyle sur un substrat. Sommaire 1 Rôle dans les cellules vivantes 1.1 La méthylation de l ADN … Wikipédia en Français
DNA profiling — Not to be confused with Full genome sequencing. Forensic science … Wikipedia