cytohesin-1


cytohesin-1
(= B2-1)
Guanine nucleotide exchange factor for human ADP-ribosylation factor (ARF) GTPases. Abundant in cells of the immune system where it mediates PI3-kinase activation of b 2 integrin (particularly LFA-1) through interaction with the cytoplasmic domain. Closely related to ARNO and GRP-1; all three have a central Sec7-like domain and C-terminal pleckstrin homology (PH) domain. The PH domain and C-terminal polybasic sequence are important for membrane-association and function.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • cytohesin — noun A protein, abundant in cells of the immune system, that is a regulatory factor in lymphocytes …   Wiktionary

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  • ARF1 — ADP ribosylation factor 1, also known as ARF1, is a human gene. PBB Summary section title = summary text = ADP ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide binding… …   Wikipedia

  • Ephrin A1 — Ephrin A1, also known as EFNA1, is a human gene.cite web | title = Entrez Gene: EFNA1 ephrin A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=1942| accessdate = ] PBB Summary section title = summary text …   Wikipedia

  • ARF3 — ADP ribosylation factor 3, also known as ARF3, is a human gene.cite web | title = Entrez Gene: ARF3 ADP ribosylation factor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=377| accessdate = ] PBB Summary… …   Wikipedia


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