- cyclic nucleotide phosphodiesterases
Often casually referred to simply as phosphodiesterases. Multiple isoenzymes are known. PDE-I is calcium/calmodulin regulated and important in CNS and vasorelaxation, PDE-II is cGMP-stimulated and hydrolyzes cAMP. PDE-III regulates vascular and airway dilation, platelet aggregation, cytokine production and lipolysis; PDE-IV (inhibited by rolipram) is important in control of airway smooth muscle and inflammatory mediator release but also has a role in CNS and in regulation of gastric acid secretion. PDE-V and VI are cGMP-specific. PDE-V is involved in platelet aggregation; PDE-VI is regulated by interaction with transducin in photoreceptors. PDE-VII is abundant in skeletal muscle and present in heart and kidney.
Dictionary of molecular biology. 2004.
Look at other dictionaries:
Cyclic nucleotide phosphodiesterase — 3 5 cyclic nucleotide phosphodiesterase Identifiers Symbol PDEase I Pfam PF00233 InterPro … Wikipedia
Cyclic guanosine monophosphate — IUPAC name 2 amino 9 [(1S,6R,8R,9R) 3,9 dihydroxy 3 oxo 2,4,7 trioxa 3λ5 phosphabicyclo[4 … Wikipedia
Phosphodiesterase — A phosphodiesterase is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However,… … Wikipedia
Phosphodiesterase 2 — The PDE2 (phosphodiesterase 2) enzyme is one of 21 different phosphodiesterases (PDE) found in mammals. These different PDEs can be subdivided to 11 families (PDE1 – PDE11). The different PDEs of the same family are functionally related despite… … Wikipedia
PDE2 — The PDE2 (phosphodiesterase 2) enzyme is one of 21 different phosphodiesterases (PDE) found in mammals. These different PDEs can be subdivided to 11 families (PDE1 – PDE11). The different PDEs of the same family are functionally related despite… … Wikipedia
PDE1 — (phosphodiesterase1) is a phosphodiesterase enzyme also known as calcium and calmodulin dependent phosphodiesterase. It is one of the 11 families of phosphodiesterase (PDE1 PDE11). PDE1 has three subtypes, PDE1A, PDE1B and PDE1C which divide… … Wikipedia
PDE7A — Phosphodiesterase 7A PDB rendering based on 1zkl … Wikipedia
PDE4B — Phosphodiesterase 4B, cAMP specific PDB rendering based on 1f0j … Wikipedia
Phosphodiesterase inhibitor — A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), therefore preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and… … Wikipedia
PDE1C — Phosphodiesterase 1C, calmodulin dependent 70kDa Identifiers Symbols PDE1C; Hcam3 External IDs … Wikipedia