cooperativity


cooperativity
Phenomenon displayed by enzymes or receptors that have multiple binding sites. Binding of one ligand alters the affinity of the other site(s). Both positive and negative cooperativity are known; positive cooperativity gives rise to a sigmoidal binding curve. Cooperativity is often invoked to account for non-linearity of binding data, although it is by no means the only possible cause.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

  • Cooperativity — is a phenomenon displayed by enzymes or receptors that have multiple binding sites where the affinity of the binding sites for a ligand is increased, positive cooperativity, or decreased, negative cooperativity, upon the binding of a ligand to a… …   Wikipedia

  • cooperativity — /koh op euhr euh tiv i tee/, n. Biochem. the increase or decrease in the rate of interaction between a reactant and a protein as the reactant concentration increases. Also, co operativity. [COOPERATIVE + ITY] * * * ▪ enzymology       in… …   Universalium

  • Cooperativity — …   Википедия

  • cooperativity — noun An interaction between the substrate binding sites of an allosteric enzyme in which binding at one site increases or decreases binding at another …   Wiktionary

  • cooperativity — A property of certain proteins (often enzymes) in which the binding curves or saturation curves or, in the case of enzymes, a plot of initial rates as a function of initial substrate concentration, are nonhyperbolic; suggests that the binding of… …   Medical dictionary

  • cooperativity — /koh op euhr euh tiv i tee/, n. Biochem. the increase or decrease in the rate of interaction between a reactant and a protein as the reactant concentration increases. Also, co operativity. [COOPERATIVE + ITY] …   Useful english dictionary

  • negative cooperativity — cooperativity in which the dissociation constant for each successive ligand bound is higher than for the one preceding it, so that the binding affinity is successively decreased …   Medical dictionary

  • positive cooperativity — cooperativity in which the dissociation constant for each successive ligand bound is lower than for the one preceding it, so that the binding affinity is successively increased …   Medical dictionary

  • Cooperative binding — In biochemistry, a macromolecule exhibits cooperative binding if its affinity for its ligand changes with the amount of ligand already bound. Cooperative binding is a special case of allostery. Cooperative binding requires that the macromolecule… …   Wikipedia

  • Enzyme kinetics — is the study of the chemical reactions that are catalysed by enzymes, with a focus on their reaction rates. The study of an enzyme s kinetics reveals the catalytic mechanism of this enzyme, its role in metabolism, how its activity is controlled,… …   Wikipedia


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