- Reactive lymphocyte
The nucleus of a reactive lymphocyte can be round, elliptic, indented, cleft or folded. The cytoplasm is often abundant and can be basophilic. Vacuoles and/or azurophilic granules are also sometimes present. Most often the cytoplasm is gray, pale blue or deep blue in colour.
The distinctive cell associated with EBV or CMV is known as a "Downey cell", after Hal Downey, who contributed to the characterization of it in 1923. It is sometimes erroneously called a "Downy cell".
Reactive lymphocytes are usually associated with viral illnesses, however, they can also be present as a result of drug reactions (such as phenytoin), immunisations, radiation, hormonal causes (such as stress and Addison's disease) as well as some auto-immune disorders (such as rheumatoid arthritis).
Some pathogen-related causes include:
- Epstein-Barr virus
- Treponema pallidum (Syphilis)
- Streptococcus agalactiae (Group B Streptococci),
- Hepatitis C
- Review Article: The Atypical Lymphocyte- International Pediatrics Volume 18, No. 1; Michael W. Simon.
- Educational Commentary: Blood Cell Identification - American Society for Clinical Pathology article.
- ^ Cabot, Richard C.; Scully, Robert E.; Mark, Eugene J.; McNeely, William F.; McNeely, Betty U.; Rosenfield, Cathy G.; Kaplan, Mark A. (June 1994). "Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 24-1994. A two-year-old boy with thrombocytopenia, leukocytosis, and hepatosplenomegaly". N. Engl. J. Med. 330 (24): 1739–46. doi:10.1056/NEJM199406163302408. PMID 8190136. http://content.nejm.org/cgi/pmidlookup?view=short&pmid=8190136&promo=ONFLNS19.
- ^ Downey H, McKinlay CA. Acute Lymphadenosis Compared with Acute Lymphatic Leukemia. Arch Intern Med. 1923;32:82-112
- ^ "MedlinePlus Medical Encyclopedia: Mononucleosis, photomicrograph of cells". http://www.nlm.nih.gov/medlineplus/ency/imagepages/1456.htm. Retrieved 2009-03-07.
- ^ Peters CJ, Khan AS (2002). "Hantavirus pulmonary syndrome: the new American hemorrhagic fever". Clin Infect Dis 34 (9): 1224–31. doi:10.1086/339864. PMID 11941549.
Lymphoid system (TA A13.1–2, TH H3.10, GA 8 and 9) Primary lymphoid organs Secondary lymphoid organs· Subcapsular sinus · Cortex · Paracortex · Medulla (Medullary cord) · HilumMALT
anat(h, u, t, a, l)/phys/depv
Abnormal clinical and laboratory findings for blood tests (R70–R79, 790) Red blood cellsSizeShape (Poikilocyte)Other LymphocytesSmudge cell · Downey cell Small moleculesNitrogenous ProteinsOtherElevated cardiac markers · Elevated alpha-fetoprotein Minerals Pathogens/sepsis
Wikimedia Foundation. 2010.
Look at other dictionaries:
Lymphocyte — A lymphocyte is a type of white blood cell in the vertebrate immune system. By their appearance under the light microscope, there are two broad categories of lymphocytes, namely the large granular lymphocytes and the small lymphocytes.… … Wikipedia
Nodular lymphocyte predominant Hodgkin's lymphoma — Classification and external resources Micrograph of a lymph node biopsy showi … Wikipedia
C-reactive protein — C reactive protein, pentraxin related Constructed from 1B09 … Wikipedia
Cellule de Downey — Les cellules de Downey sont des lymphocytes T activés atypiques, observés en particulier dans les infections au virus d Epstein Barr ou celles au cytomegalovirus. Le nom de Downey a été donné d après Hal Downey qui contribua à leur… … Wikipédia en Français
immunological tolerance — Specific unresponsiveness to antigen. Self tolerance is a process occurring normally early in life due to suppression of self reactive lymphocyte clones. Tolerance to foreign antigens can be induced in adult life by exposure to antigens under… … Dictionary of molecular biology
immune system — Anat. a diffuse, complex network of interacting cells, cell products, and cell forming tissues that protects the body from pathogens and other foreign substances, destroys infected and malignant cells, and removes cellular debris: the system… … Universalium
Hodgkin's lymphoma — Hodgkin lymphoma Classification and external resources Micrograph showing Hodgkin s lymphoma (Field stain). ICD 10 C … Wikipedia
Cell — The basic structural and functional unit in people and all living things. Each cell is a small container of chemicals and water wrapped in a membrane. Each cell in the human body there are 100 trillion cells in each of us contains the entire… … Medical dictionary
immune system disorder — Introduction Disorders of the immune systemany of various failures in the body s defense mechanisms against infectious organisms (see table (Disorders of the immune system)). Disorders of immunity include immune deficiency diseases, such… … Universalium
Central tolerance — is the mechanism by which newly developing T cells and B cells are rendered non reactive to self. The concept of central tolerance was proposed in 1959 by Joshua Lederberg, as part of his general theory of immunity and tolerance, and is… … Wikipedia