CASP8 associated protein 2, also known as CASP8AP2, is a human gene.cite web | title = Entrez Gene: CASP8AP2 CASP8 associated protein 2| url =| accessdate = ]

section_title =
summary_text = This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis.cite web | title = Entrez Gene: CASP8AP2 CASP8 associated protein 2| url =| accessdate = ]


Further reading

citations =
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*cite journal | author=Imai Y, Kimura T, Murakami A, "et al." |title=The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis. |journal=Nature |volume=398 |issue= 6730 |pages= 777–85 |year= 1999 |pmid= 10235259 |doi= 10.1038/19709
*cite journal | author=Koonin EV, Aravind L, Hofmann K, "et al." |title=Apoptosis. Searching for FLASH domains. |journal=Nature |volume=401 |issue= 6754 |pages= 662; discussion 662–3 |year= 1999 |pmid= 10537104 |doi= 10.1038/44317
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*cite journal | author=Kino T, Chrousos GP |title=Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators. |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 3023–9 |year= 2003 |pmid= 12477726 |doi= 10.1074/jbc.M209234200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Jun JI, Chung CW, Lee HJ, "et al." |title=Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway. |journal=Oncogene |volume=24 |issue= 4 |pages= 688–96 |year= 2005 |pmid= 15592525 |doi= 10.1038/sj.onc.1208186
*cite journal | author=Kino T, Ichijo T, Chrousos GP |title=FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors. |journal=J. Steroid Biochem. Mol. Biol. |volume=92 |issue= 5 |pages= 357–63 |year= 2005 |pmid= 15698540 |doi= 10.1016/j.jsbmb.2004.09.003
*cite journal | author=Flotho C, Coustan-Smith E, Pei D, "et al." |title=Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2. |journal=Blood |volume=108 |issue= 3 |pages= 1050–7 |year= 2006 |pmid= 16627760 |doi= 10.1182/blood-2006-01-0322
*cite journal | author=Barcaroli D, Bongiorno-Borbone L, Terrinoni A, "et al." |title=FLASH is required for histone transcription and S-phase progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 40 |pages= 14808–12 |year= 2006 |pmid= 17003125 |doi= 10.1073/pnas.0604227103
*cite journal | author=Barcaroli D, Dinsdale D, Neale MH, "et al." |title=FLASH is an essential component of Cajal bodies. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 40 |pages= 14802–7 |year= 2006 |pmid= 17003126 |doi= 10.1073/pnas.0604225103
*cite journal | author=Milovic-Holm K, Krieghoff E, Jensen K, "et al." |title=FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies. |journal=EMBO J. |volume=26 |issue= 2 |pages= 391–401 |year= 2007 |pmid= 17245429 |doi= 10.1038/sj.emboj.7601504
*cite journal | author=Jeong EG, Lee SH, Lee HW, "et al." |title=Immunohistochemical and mutational analysis of FLASH in gastric carcinomas. |journal=APMIS |volume=115 |issue= 8 |pages= 900–5 |year= 2007 |pmid= 17696945 |doi= 10.1111/j.1600-0463.2007.apm_706.x

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