UBE2E3


UBE2E3

Ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast), also known as UBE2E3, is a human gene.cite web | title = Entrez Gene: UBE2E3 ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10477| accessdate = ]

PBB_Summary
section_title =
summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.cite web | title = Entrez Gene: UBE2E3 ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10477| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hay RT, Vuillard L, Desterro JM, Rodriguez MS |title=Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=354 |issue= 1389 |pages= 1601–9 |year= 2000 |pmid= 10582246 |doi= 10.1098/rstb.1999.0504
*cite journal | author=Desterro JM, Thomson J, Hay RT |title=Ubch9 conjugates SUMO but not ubiquitin. |journal=FEBS Lett. |volume=417 |issue= 3 |pages= 297–300 |year= 1998 |pmid= 9409737 |doi=
*cite journal | author=Desterro JM, Rodriguez MS, Hay RT |title=SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. |journal=Mol. Cell |volume=2 |issue= 2 |pages= 233–9 |year= 1998 |pmid= 9734360 |doi=
*cite journal | author=Desterro JM, Rodriguez MS, Kemp GD, Hay RT |title=Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10618–24 |year= 1999 |pmid= 10187858 |doi=
*cite journal | author=Ito K, Kato S, Matsuda Y, "et al." |title=cDNA cloning, characterization, and chromosome mapping of UBE2E3 (alias UbcH9), encoding an N-terminally extended human ubiquitin-conjugating enzyme. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 1-2 |pages= 99–104 |year= 1999 |pmid= 10343118 |doi=
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*cite journal | author=Ito K, Adachi S, Iwakami R, "et al." |title=N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. |journal=Eur. J. Biochem. |volume=268 |issue= 9 |pages= 2725–32 |year= 2001 |pmid= 11322894 |doi=
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*cite journal | author=Plafker SM, Plafker KS, Weissman AM, Macara IG |title=Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import. |journal=J. Cell Biol. |volume=167 |issue= 4 |pages= 649–59 |year= 2005 |pmid= 15545318 |doi= 10.1083/jcb.200406001
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*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032

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