Receptor-interacting serine-threonine kinase 2, also known as RIPK2, is a human gene.cite web | title = Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2| url =| accessdate = ]

section_title =
summary_text = This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.cite web | title = Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Medzhitov R, Janeway C |title=Innate immune recognition: mechanisms and pathways. |journal=Immunol. Rev. |volume=173 |issue= |pages= 89–97 |year= 2000 |pmid= 10719670 |doi=
*cite journal | author=Dufner A, Mak TW |title=CARD tricks: controlling the interactions of CARD6 with RICK and microtubules. |journal=Cell Cycle |volume=5 |issue= 8 |pages= 797–800 |year= 2006 |pmid= 16582588 |doi=
*cite journal | author=Inohara N, del Peso L, Koseki T, "et al." |title=RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. |journal=J. Biol. Chem. |volume=273 |issue= 20 |pages= 12296–300 |year= 1998 |pmid= 9575181 |doi=
*cite journal | author=McCarthy JV, Ni J, Dixit VM |title=RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 16968–75 |year= 1998 |pmid= 9642260 |doi=
*cite journal | author=Thome M, Hofmann K, Burns K, "et al." |title=Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. |journal=Curr. Biol. |volume=8 |issue= 15 |pages= 885–8 |year= 1998 |pmid= 9705938 |doi=
*cite journal | author=Bertin J, Nir WJ, Fischer CM, "et al." |title=Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 12955–8 |year= 1999 |pmid= 10224040 |doi=
*cite journal | author=Inohara N, Koseki T, del Peso L, "et al." |title=Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 14560–7 |year= 1999 |pmid= 10329646 |doi=
*cite journal | author=Navas TA, Baldwin DT, Stewart TA |title=RIP2 is a Raf1-activated mitogen-activated protein kinase kinase. |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33684–90 |year= 1999 |pmid= 10559258 |doi=
*cite journal | author=Inohara N, Koseki T, Lin J, "et al." |title=An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 27823–31 |year= 2000 |pmid= 10880512 |doi= 10.1074/jbc.M003415200
*cite journal | author=Ogura Y, Inohara N, Benito A, "et al." |title=Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4812–8 |year= 2001 |pmid= 11087742 |doi= 10.1074/jbc.M008072200
*cite journal | author=Lee SH, Stehlik C, Reed JC |title=Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34495–500 |year= 2001 |pmid= 11432859 |doi= 10.1074/jbc.M101415200
*cite journal | author=Khursigara G, Bertin J, Yano H, "et al." |title=A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2. |journal=J. Neurosci. |volume=21 |issue= 16 |pages= 5854–63 |year= 2001 |pmid= 11487608 |doi=
*cite journal | author=Druilhe A, Srinivasula SM, Razmara M, "et al." |title=Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. |journal=Cell Death Differ. |volume=8 |issue= 6 |pages= 649–57 |year= 2001 |pmid= 11536016 |doi= 10.1038/sj/cdd/4400881
*cite journal | author=Chin AI, Dempsey PW, Bruhn K, "et al." |title=Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. |journal=Nature |volume=416 |issue= 6877 |pages= 190–4 |year= 2002 |pmid= 11894097 |doi= 10.1038/416190a
*cite journal | author=Kobayashi K, Inohara N, Hernandez LD, "et al." |title=RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. |journal=Nature |volume=416 |issue= 6877 |pages= 194–9 |year= 2002 |pmid= 11894098 |doi= 10.1038/416194a
*cite journal | author=Munz B, Hildt E, Springer ML, Blau HM |title=RIP2, a checkpoint in myogenic differentiation. |journal=Mol. Cell. Biol. |volume=22 |issue= 16 |pages= 5879–86 |year= 2002 |pmid= 12138198 |doi=
*cite journal | author=Yoo NJ, Park WS, Kim SY, "et al." |title=Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 4 |pages= 652–8 |year= 2003 |pmid= 12459189 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chen YR, Clark AC |title=Equilibrium and kinetic folding of an alpha-helical Greek key protein domain: caspase recruitment domain (CARD) of RICK. |journal=Biochemistry |volume=42 |issue= 20 |pages= 6310–20 |year= 2003 |pmid= 12755636 |doi= 10.1021/bi0340752

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