G protein-coupled receptor 143
Symbols GPR143; NYS6; OA1
External IDs OMIM300808 MGI107193 HomoloGene230 IUPHAR: GPR143 GeneCards: GPR143 Gene
RNA expression pattern
PBB GE GPR143 206696 at tn.png
More reference expression data
Species Human Mouse
Entrez 4935 18241
Ensembl ENSG00000101850 ENSMUSG00000025333
UniProt P51810 Q549B6
RefSeq (mRNA) NM_000273 NM_010951.3
RefSeq (protein) NP_000264 NP_035081.3
Location (UCSC) Chr X:
9.69 – 9.75 Mb
Chr X:
149.22 – 149.24 Mb
PubMed search [1] [2]

G-protein coupled receptor 143 is a protein that in humans is encoded by the GPR143 gene.[1][2][3]

Ocular albinism type 1 protein is a conserved integral membrane protein with seven transmembrane domains. It is expressed in the eye and epidermal melanocytes.[3]

The GPR143 gene is regulated by the Microphthalmia-associated transcription factor.[4][5]

L-DOPA is an endogenous ligand for OA1.[6]



GPR143 has been shown to interact with GNAI1.[2]


  1. ^ Bassi MT, Schiaffino MV, Renieri A, De Nigris F, Galli L, Bruttini M, Gebbia M, Bergen AA, Lewis RA, Ballabio A (Sep 1995). "Cloning of the gene for ocular albinism type 1 from the distal short arm of the X chromosome". Nat Genet 10 (1): 13–9. doi:10.1038/ng0595-13. PMID 7647783. 
  2. ^ a b Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi MT, Colla C, De Luca M, Tacchetti C, Ballabio A (Sep 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system". Nat Genet 23 (1): 108–12. doi:10.1038/12715. PMID 10471510. 
  3. ^ a b "Entrez Gene: GPR143 G protein-coupled receptor 143". 
  4. ^ Vetrini F, Auricchio A, Du J, et al. (2004). "The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis". Mol. Cell. Biol. 24 (15): 6550–9. doi:10.1128/MCB.24.15.6550-6559.2004. PMC 444869. PMID 15254223. 
  5. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  6. ^ Lopez VM, Decatur CL, Stamer WD, Lynch RM, McKay BS (September 2008). Barsh, Gregory S.. ed. "L-DOPA is an endogenous ligand for OA1". PLoS Biol. 6 (9): e236. doi:10.1371/journal.pbio.0060236. PMC 2553842. PMID 18828673. 

Further reading

External links