Alpha-2C adrenergic receptor


Alpha-2C adrenergic receptor

The alpha-2C adrenergic receptor2C adrenoreceptor), also known as ADRA2C, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.

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Receptor

Alpha-2-adrenergic receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity.

Gene

This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.cite web | title = Entrez Gene: ADRA2C adrenergic, alpha-2C-, receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=152| accessdate = ]

ee also

*Adrenergic receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Coupry I, Duzic E, Lanier SM |title=Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. II. Preferential coupling of the alpha 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go. |journal=J. Biol. Chem. |volume=267 |issue= 14 |pages= 9852–7 |year= 1992 |pmid= 1349607 |doi=
*cite journal | author=Chhajlani V, Rangel N, Uhlén S, Wikberg JE |title=Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR. |journal=FEBS Lett. |volume=280 |issue= 2 |pages= 241–4 |year= 1991 |pmid= 1849485 |doi=
*cite journal | author=Regan JW, Kobilka TS, Yang-Feng TL, "et al." |title=Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 17 |pages= 6301–5 |year= 1988 |pmid= 2842764 |doi=
*cite journal | author=Eason MG, Liggett SB |title=Human alpha 2-adrenergic receptor subtype distribution: widespread and subtype-selective expression of alpha 2C10, alpha 2C4, and alpha 2C2 mRNA in multiple tissues. |journal=Mol. Pharmacol. |volume=44 |issue= 1 |pages= 70–5 |year= 1993 |pmid= 7688069 |doi=
*cite journal | author=Riess O, Thies U, Siedlaczck I, "et al." |title=Precise mapping of the brain alpha 2-adrenergic receptor gene within chromosome 4p16. |journal=Genomics |volume=19 |issue= 2 |pages= 298–302 |year= 1994 |pmid= 8188260 |doi= 10.1006/geno.1994.1061
*cite journal | author=Klein U, Ramirez MT, Kobilka BK, von Zastrow M |title=A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B. |journal=J. Biol. Chem. |volume=272 |issue= 31 |pages= 19099–102 |year= 1997 |pmid= 9235896 |doi=
*cite journal | author=Schaak S, Devedjian JC, Cayla C, "et al." |title=Molecular cloning, sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene. |journal=Biochem. J. |volume=328 ( Pt 2) |issue= |pages= 431–8 |year= 1998 |pmid= 9371698 |doi=
*cite journal | author=DeGraff JL, Gagnon AW, Benovic JL, Orsini MJ |title=Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11253–9 |year= 1999 |pmid= 10196213 |doi=
*cite journal | author=Prezeau L, Richman JG, Edwards SW, Limbird LE |title=The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13462–9 |year= 1999 |pmid= 10224112 |doi=
*cite journal | author=Hein L, Altman JD, Kobilka BK |title=Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission. |journal=Nature |volume=402 |issue= 6758 |pages= 181–4 |year= 2000 |pmid= 10647009 |doi= 10.1038/46040
*cite journal | author=Small KM, Forbes SL, Rahman FF, "et al." |title=A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23059–64 |year= 2000 |pmid= 10801795 |doi= 10.1074/jbc. M000796200
*cite journal | author=Comings DE, Gade-Andavolu R, Gonzalez N, "et al." |title=Multivariate analysis of associations of 42 genes in ADHD, ODD and conduct disorder. |journal=Clin. Genet. |volume=58 |issue= 1 |pages= 31–40 |year= 2001 |pmid= 10945659 |doi=
*cite journal | author=Small KM, Wagoner LE, Levin AM, "et al." |title=Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. |journal=N. Engl. J. Med. |volume=347 |issue= 15 |pages= 1135–42 |year= 2002 |pmid= 12374873 |doi= 10.1056/NEJMoa020803
*cite journal | author=Chotani MA, Mitra S, Su BY, "et al." |title=Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=286 |issue= 1 |pages= H59–67 |year= 2004 |pmid= 12946937 |doi= 10.1152/ajpheart.00268.2003
*cite journal | author=Small KM, Mialet-Perez J, Seman CA, "et al." |title=Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 35 |pages= 13020–5 |year= 2004 |pmid= 15319474 |doi= 10.1073/pnas.0405074101
*cite journal | author=Chotani MA, Mitra S, Eid AH, "et al." |title=Distinct cAMP signaling pathways differentially regulate alpha2C-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=288 |issue= 1 |pages= H69–76 |year= 2005 |pmid= 15345481 |doi= 10.1152/ajpheart.01223.2003
*cite journal | author=Belfer I, Buzas B, Hipp H, "et al." |title=Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene. |journal=J. Hum. Genet. |volume=50 |issue= 1 |pages= 12–20 |year= 2005 |pmid= 15592690 |doi= 10.1007/s10038-004-0211-y
*cite journal | author=Neumeister A, Charney DS, Belfer I, "et al." |title=Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans. |journal=Pharmacogenet. Genomics |volume=15 |issue= 3 |pages= 143–9 |year= 2005 |pmid= 15861038 |doi=
*cite journal | author=Neumeister A, Drevets WC, Belfer I, "et al." |title=Effects of an alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression. |journal=Neuropsychopharmacology |volume=31 |issue= 8 |pages= 1750–6 |year= 2006 |pmid= 16407897 |doi= 10.1038/sj.npp.1301010
*cite journal | author=Park JS, Zhang SY, Jo SH, "et al." |title=Common adrenergic receptor polymorphisms as novel risk factors for vasospastic angina. |journal=Am. Heart J. |volume=151 |issue= 4 |pages= 864–9 |year= 2006 |pmid= 16569551 |doi= 10.1016/j.ahj.2005.06.009

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