Coagulation factor II receptor


Coagulation factor II receptor
Coagulation factor II (thrombin) receptor

Rendering of F2R from PDB 1NRN
Identifiers
Symbols F2R; CF2R; HTR; PAR-1; PAR1; TR
External IDs OMIM187930 MGI101802 HomoloGene1510 GeneCards: F2R Gene
RNA expression pattern
PBB GE F2R 203989 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2149 14062
Ensembl ENSG00000181104 ENSMUSG00000048376
UniProt P25116 Q3UK34
RefSeq (mRNA) NM_001992 NM_010169.3
RefSeq (protein) NP_001983 NP_034299.2
Location (UCSC) Chr 5:
76.01 – 76.03 Mb
Chr 13:
96.37 – 96.39 Mb
PubMed search [1] [2]

Proteinase-activated receptor 1 (PAR1) also known as the coagulation factor II (thrombin) receptor is a protein that in humans is encoded by the F2R gene.[1] PAR1 is a G protein-coupled receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor.[2]

Contents

Ligands

Several selective antagonists for the PAR1 receptor have been developed, for use as anti-clotting agents for the treatment of heart disease.

  • SCH-530,348

See also

References

  1. ^ Bahou WF, Nierman WC, Durkin AS, Potter CL, Demetrick DJ (September 1993). "Chromosomal assignment of the human thrombin receptor gene: localization to region q13 of chromosome 5". Blood 82 (5): 1532–7. PMID 8395910. 
  2. ^ "Entrez Gene: F2R coagulation factor II (thrombin) receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2149. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Metabolites and
signaling molecules
Peptide
Miscellaneous
Class B: Secretin like Class C: Metabotropic
glutamate / pheromone Class F:
Frizzled / Smoothened B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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