C-C chemokine receptor type 7


C-C chemokine receptor type 7
Chemokine (C-C motif) receptor 7
Identifiers
Symbols CCR7; BLR2; CD197; CDw197; CMKBR7; EBI1
External IDs OMIM600242 MGI103011 HomoloGene1387 IUPHAR: CCR7 GeneCards: CCR7 Gene
RNA expression pattern
PBB GE CCR7 206337 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1236 12775
Ensembl ENSG00000126353 ENSMUSG00000037944
UniProt P32248 Q3U3J0
RefSeq (mRNA) NM_001838.3 NM_007719.2
RefSeq (protein) NP_001829.1 NP_031745.2
Location (UCSC) Chr 17:
38.71 – 38.72 Mb
Chr 11:
99.01 – 99.02 Mb
PubMed search [1] [2]

C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene.[1]

CCR7 has also recently been designated CD197 (cluster of differentiation 197).

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells home to secondary lympho-organ, such as lympho-nodes, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ELC) has been reported to be a specific ligand of this receptor.[2]

References

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

TNF receptor JAK-STAT Ig superfamily
CSF1 · KIT · IL1 (IL1R1, IL1R2· IL18R/IL18R1
IL-17 family
IL-17 (IL17RA, IL17RB, IL17RC, IL17RD, IL17RE)
S/T
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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