Calmodulin 1


Calmodulin 1
Calmodulin 1 (phosphorylase kinase, delta)

PDB rendering based on 1a29.
Identifiers
Symbols CALM1; CALM2; CALM3; CALML2; CAMI; DD132; PHKD; caM
External IDs OMIM114180 MGI88251 HomoloGene111276 GeneCards: CALM1 Gene
EC number 2.7.11.19
Orthologs
Species Human Mouse
Entrez 801 640703
Ensembl ENSG00000198668 ENSMUSG00000001175
UniProt P62158 P62204
RefSeq (mRNA) NM_001166106.1 NM_009790
RefSeq (protein) NP_001159578.1 NP_033920
Location (UCSC) Chr 14:
90.86 – 90.87 Mb
Chr 12:
101.44 – 101.45 Mb
PubMed search [1] [2]

Calmodulin 1 is a protein that in humans is encoded by the CALM1 gene.[1]

Contents

Function

Calmodulin 1 is the archetype of the family of calcium-modulated (calmodulin) proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 148 amino acids and has 4 calcium-binding motifs. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters.[2]

Interactions

Calmodulin 1 has been shown to interact with AKAP9,[3] TRPV1,[4] Androgen receptor,[5] IQGAP1[6][7] and PPEF1.[8]

References

  1. ^ Wawrzynczak EJ, Perham RN (August 1984). "Isolation and nucleotide sequence of a cDNA encoding human calmodulin". Biochem. Int. 9 (2): 177–85. PMID 6385987. 
  2. ^ "Entrez Gene: CALM1 calmodulin 1 (phosphorylase kinase, delta)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=801. 
  3. ^ Takahashi, Mikiko; Yamagiwa Akiko, Nishimura Tamako, Mukai Hideyuki, Ono Yoshitaka (Sep. 2002). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell (United States) 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. ISSN 1059-1524. PMC 124155. PMID 12221128. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=124155. 
  4. ^ Numazaki, Mitsuko; Tominaga Tomoko, Takeuchi Kumiko, Murayama Namie, Toyooka Hidenori, Tominaga Makoto (Jun. 2003). "Structural determinant of TRPV1 desensitization interacts with calmodulin". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (13): 8002–6. doi:10.1073/pnas.1337252100. ISSN 0027-8424. PMC 164702. PMID 12808128. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=164702. 
  5. ^ Cifuentes, Eugenia; Mataraza Jennifer M, Yoshida Barbara A, Menon Mani, Sacks David B, Barrack Evelyn R, Reddy G Prem-Veer (Jan. 2004). "Physical and functional interaction of androgen receptor with calmodulin in prostate cancer cells". Proc. Natl. Acad. Sci. U.S.A. (United States) 101 (2): 464–9. doi:10.1073/pnas.0307161101. ISSN 0027-8424. PMC 327170. PMID 14695896. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=327170. 
  6. ^ Li, Zhigang; Sacks David B (Feb. 2003). "Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1". J. Biol. Chem. (United States) 278 (6): 4347–52. doi:10.1074/jbc.M208579200. ISSN 0021-9258. PMID 12446675. 
  7. ^ Briggs, Michael W; Li Zhigang, Sacks David B (Mar. 2002). "IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin". J. Biol. Chem. (United States) 277 (9): 7453–65. doi:10.1074/jbc.M104315200. ISSN 0021-9258. PMID 11734550. 
  8. ^ Kutuzov, Mikhail A; Solov'eva Olga V, Andreeva Alexandra V, Bennett Nelly (May. 2002). "Protein Ser/Thr phosphatases PPEF interact with calmodulin". Biochem. Biophys. Res. Commun. (United States) 293 (3): 1047–52. doi:10.1016/S0006-291X(02)00338-8. ISSN 0006-291X. PMID 12051765. 

Further reading

  • Zhang M, Yuan T (1999). "Molecular mechanisms of calmodulin's functional versatility". Biochem. Cell Biol. 76 (2–3): 313–23. doi:10.1139/bcb-76-2-3-313. PMID 9923700. 
  • Gusev NB (2002). "Some properties of caldesmon and calponin and the participation of these proteins in regulation of smooth muscle contraction and cytoskeleton formation". Biochemistry Mosc. 66 (10): 1112–21. doi:10.1023/A:1012480829618. PMID 11736632. 
  • Benaim G, Villalobo A (2002). "Phosphorylation of calmodulin. Functional implications". Eur. J. Biochem. 269 (15): 3619–31. doi:10.1046/j.1432-1033.2002.03038.x. PMID 12153558. 
  • Trudeau MC, Zagotta WN (2003). "Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels". J. Biol. Chem. 278 (21): 18705–8. doi:10.1074/jbc.R300001200. PMID 12626507. 

External links