Alpha 2-antiplasmin

Alpha 2-antiplasmin

Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin, an important enzyme that participates in fibrinolysis and degradation of various other proteins. This protein is encoded by the SERPINF2 gene.cite web | title = Entrez Gene: SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2| url =| accessdate = ]

Role in disease

Very few cases (<20) of A2AP deficiency have been described. As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported.

ee also

* Serpin


Further reading

citations =
*cite journal | author=Martí-Fàbregas J, Borrell M, Cocho D, "et al." |title=Change in hemostatic markers after recombinant tissue-type plasminogen activator is not associated with the chance of recanalization |journal=Stroke |volume=39 |issue= 1 |pages= 234–6 |year= 2008 |pmid= 18048863 |doi= 10.1161/STROKEAHA.107.493767
*cite journal | author=Nielsen VG |title=Hydroxyethyl starch enhances fibrinolysis in human plasma by diminishing alpha2-antiplasmin-plasmin interactions |journal=Blood Coagul. Fibrinolysis |volume=18 |issue= 7 |pages= 647–56 |year= 2007 |pmid= 17890952 |doi= 10.1097/MBC.0b013e3282a167dc |doi_brokendate=2008-06-22
*cite journal | author=Sazonova IY, Thomas BM, Gladysheva IP, "et al." |title=Fibrinolysis is amplified by converting alpha-antiplasmin from a plasmin inhibitor to a substrate |journal=J. Thromb. Haemost. |volume=5 |issue= 10 |pages= 2087–94 |year= 2007 |pmid= 17883703 |doi= 10.1111/j.1538-7836.2007.02652.x
*cite journal | author=Mutch NJ, Thomas L, Moore NR, "et al." |title=TAFIa, PAI-1 and alpha-antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots |journal=J. Thromb. Haemost. |volume=5 |issue= 4 |pages= 812–7 |year= 2007 |pmid= 17388801 |doi= 10.1111/j.1538-7836.2007.02430.x
*cite journal | author=Christiansen VJ, Jackson KW, Lee KN, McKee PA |title=The effect of a single nucleotide polymorphism on human alpha 2-antiplasmin activity |journal=Blood |volume=109 |issue= 12 |pages= 5286–92 |year= 2007 |pmid= 17317851 |doi= 10.1182/blood-2007-01-065185
*cite journal | author=Hayashido Y, Hamana T, Ishida Y, "et al." |title=Induction of alpha2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion |journal=Oncol. Rep. |volume=17 |issue= 2 |pages= 417–23 |year= 2007 |pmid= 17203182 |doi=
*cite journal | author=Shibata N, Kawarai T, Meng Y, "et al." |title=Association studies between the plasmin genes and late-onset Alzheimer's disease |journal=Neurobiol. Aging |volume=28 |issue= 7 |pages= 1041–3 |year= 2007 |pmid= 16828203 |doi= 10.1016/j.neurobiolaging.2006.05.028
*cite journal | author=Liu T, Qian WJ, Gritsenko MA, "et al." |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065
*cite journal | author=Lee KN, Jackson KW, Christiansen VJ, "et al." |title=A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion |journal=Blood |volume=103 |issue= 10 |pages= 3783–8 |year= 2004 |pmid= 14751930 |doi= 10.1182/blood-2003-12-4240
*cite journal | author=Anderson NL, Polanski M, Pieper R, "et al." |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources |journal=Mol. Cell Proteomics |volume=3 |issue= 4 |pages= 311–26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200
*cite journal | author=Kapadia C, Yousef GM, Mellati AA, "et al." |title=Complex formation between human kallikrein 13 and serum protease inhibitors |journal=Clin. Chim. Acta |volume=339 |issue= 1-2 |pages= 157–67 |year= 2004 |pmid= 14687906 |doi=10.1016/j.cccn.2003.10.009
*cite journal | author=Matsuno H, Okada K, Ueshima S, "et al." |title=Alpha2-antiplasmin plays a significant role in acute pulmonary embolism |journal=J. Thromb. Haemost. |volume=1 |issue= 8 |pages= 1734–9 |year= 2004 |pmid= 12911586 |doi=10.1046/j.1538-7836.2003.00252.x
*cite journal | author=Magklara A, Mellati AA, Wasney GA, "et al." |title=Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors |journal=Biochem. Biophys. Res. Commun. |volume=307 |issue= 4 |pages= 948–55 |year= 2003 |pmid= 12878203 |doi=10.1016/S0006-291X(03)01271-3
*cite journal | author=Cardoso C, Leventer RJ, Ward HL, "et al." |title=Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3 |journal=Am. J. Hum. Genet. |volume=72 |issue= 4 |pages= 918–30 |year= 2003 |pmid= 12621583 |doi=10.1086/374320
*cite journal | author=Frank PS, Douglas JT, Locher M, "et al." |title=Structural/functional characterization of the alpha 2-plasmin inhibitor C-terminal peptide |journal=Biochemistry |volume=42 |issue= 4 |pages= 1078–85 |year= 2003 |pmid= 12549929 |doi= 10.1021/bi026917n
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Turner RB, Liu L, Sazonova IY, Reed GL |title=Structural elements that govern the substrate specificity of the clot-dissolving enzyme plasmin |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 33068–74 |year= 2002 |pmid= 12080056 |doi= 10.1074/jbc.M203782200
*cite journal | author=Askew YS, Pak SC, Luke CJ, "et al." |title=SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases |journal=J. Biol. Chem. |volume=276 |issue= 52 |pages= 49320–30 |year= 2002 |pmid= 11604408 |doi= 10.1074/jbc.M108879200
*cite journal | author=Uszynski M, Klyszejko A, Zekanowska E |title=Plasminogen, alpha(2)-antiplasmin and complexes of plasmin-alpha(2)-antiplasmin (PAP) in amniotic fluid and blood plasma of parturient women |journal=Eur. J. Obstet. Gynecol. Reprod. Biol. |volume=93 |issue= 2 |pages= 167–71 |year= 2001 |pmid= 11074138 |doi=10.1016/S0301-2115(00)00283-9
*cite journal | author=Hevessy Z, Patthy A, Kárpáti L, Muszbek L |title=alpha(2)-plasmin inhibitor is a substrate for tissue transglutaminase: an in vitro study |journal=Thromb. Res. |volume=99 |issue= 4 |pages= 399–406 |year= 2000 |pmid= 10963790 |doi=10.1016/S0049-3848(00)00261-9

External links


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