Melarsoprol Systematic (IUPAC) name (2-(4-(4,6-diamino-1,3,5-triazin-2-ylamino)phenyl)-
Clinical data AHFS/Drugs.com Pregnancy cat. ? Legal status ? Routes IV Pharmacokinetic data Bioavailability ? Metabolism ? Half-life 35 hours Excretion Renal Identifiers CAS number ATC code P01 QP51 PubChem ChemSpider UNII KEGG ChEMBL Chemical data Formula C12H15AsN6OS2 Mol. mass 398.341 g/mol SMILES & (what is this?)
Melarsoprol is also used in the treatment of trypanosomiasis, such as Chagas disease and West African sleeping sickness, the former caused by Trypanosoma cruzi and the latter by Trypanosoma brucei gambiense.
Being a toxic organic compound of arsenic, melarsoprol is a highly dangerous treatment which is only administered by injection under the supervision of a physician, as it can produce similar effects as arsenic poisoning.
Eflornithine is a more modern and far less dangerous treatment for sleeping sickness, but it is expensive, it is not widely available on the market, and most of its supply comes from donations from its manufacturer. Moreover, eflornithine is effective only for West African sleeping sickness (caused by Trypanosoma brucei gambiense); it has no effect on East African sleeping sickness (caused by Trypanosoma brucei rhodesiense).
- ^ Bisser S, N'Siesi FX, Lejon V et al. (2007). "Equivalence trial of melarsoprol and nifurtimox monotherapy and combination therapy for the treatment of second-stage Trypanosoma brucei gambiense sleeping sickness". J. Infect. Dis. 195 (3): 322–9. doi:10.1086/510534. PMID 17205469.
- ^ Bulletin of the World Health Organization vol.84 no.10 Genebra Oct. 2006 - Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo.
- ^ Chappuis F, Udayraj N, Stietenroth K, Meussen A, Bovier PA (2005). "Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis". Clin. Infect. Dis. 41 (5): 748–51. doi:10.1086/432576. PMID 16080099.
Antiparasitics – antiprotozoal agents – Excavata antiparasitics (P01) DiscicristataTrypanosomiasis TrichozoaTrichomoniasis This antiinfective drug article is a stub. You can help Wikipedia by expanding it.