Chronic superficial keratitis


Chronic superficial keratitis
Chronic superficial keratitis in a dog

Chronic superficial keratitis (CSK), also known as pannus or Uberreiter’s disease, is an inflammatory condition of the cornea in dogs, particularly seen in the German Shepherd Dog.

Contents

Affected breeds

Chronic superficial keratitis is most commonly seen in German Shepherd Dogs,[1] but it is also found in Belgian Tervurens, Greyhounds, Siberian Huskies, Australian Shepherds, and Border Collies.[2]

Cause

CSK is immune-mediated in nature, characterized by an infiltration of white blood cells into the superficial stroma of the cornea. These cells are predominately CD4-expressing T lymphocytes and to a lesser extent CD8-expressing T cells.[3] The CD4-expressing T-cells secrete gamma interferon, which causes expression of the major histocompatibility complex class II molecules in the cells of the cornea. These class II molecules cause further inflammation by interacting with the T cells and triggering an immune response.[4] Ultraviolet light is important in the genesis of the disease which is seen at higher prevalence at elevated altitude[5] and has a seasonal variation with most cases occurring in the summer. There is likely also a genetic component to the cause of CSK due to its predominance in certain breeds.

Signs and symptoms

CSK is usually a bilateral progressive condition, however the lesions are not symmetrical nor are they painful. Signs include pigmentation and vascularization of the cornea (extension of blood vessels onto the cornea). It is usually first seen at the lateral (temporal) limbus (the junction between the cornea and sclera), although it eventually can extend from any part of the limbus to cover the entire cornea. Severe cases can cause blindness. Although CSK is usually identifiable by the appearance of the eye and the breed of the affected dog, cytology will reveal the presence of lymphocytes and plasma cells.[6]

Treatment

Treatment of CSK is usually with topical corticosteroids or topical cyclosporine, but any treatment only controls and reduces the inflammation rather than providing a cure.[7] Other investigated treatments include pimecrolimus, a derivative of ascomycin that interferes with T cell activation and inhibits the production of inflammatory cytokines.[8] Strontium-90 radiation therapy is also used to treat CSK.[9] Canine sunglasses have also been used to help protect the eyes of dogs with CSK to prevent further damage from ultraviolet radiation.[10]

See also

  • Uveal cyst
  • Meibomian cyst

References

  1. ^ Stanley R (1988). "Superficial stromal keratitis in the dog". Aust. Vet. J. 65 (10): 321–3. doi:10.1111/j.1751-0813.1988.tb14515.x. PMID 3058108. 
  2. ^ "Cornea". The Merck Veterinary Manual. 2006. http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/30109.htm. Retrieved 2007-04-28. 
  3. ^ Williams D (1999). "Histological and immunohistochemical evaluation of canine chronic superficial keratitis". Res. Vet. Sci. 67 (2): 191–5. doi:10.1053/rvsc.1999.0329. PMID 10502491. 
  4. ^ Williams D (2005). "Major histocompatibility class II expression in the normal canine cornea and in canine chronic superficial keratitis". Veterinary ophthalmology 8 (6): 395–400. doi:10.1111/j.1463-5224.2005.00412.x. PMID 16359362. 
  5. ^ Chavkin M, Roberts S, Salman M, Severin G, Scholten N (1994). "Risk factors for development of chronic superficial keratitis in dogs". J. Am. Vet. Med. Assoc. 204 (10): 1630–4. PMID 8050943. 
  6. ^ Gilger, B.C. (2006). "Ocular Cytology - Your Key to Immediate Ocular Diagnosis". Proceedings of the North American Veterinary Conference. http://www.ivis.org/proceedings/navc/2006/SAE/306.asp?LA=1. Retrieved 2007-04-28. 
  7. ^ Sapienza, John S. (2002). "Corneal Diseases of Dogs and Cats". Proceedings of the 27th World Congress of the World Small Animal Veterinary Association. http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2002&PID=2647. Retrieved 2007-04-28. 
  8. ^ Nell B, Walde I, Billich A, Vit P, Meingassner J (2005). "The effect of topical pimecrolimus on keratoconjunctivitis sicca and chronic superficial keratitis in dogs: results from an exploratory study". Veterinary ophthalmology 8 (1): 39–46. doi:10.1111/j.1463-5224.2005.04062.x. PMID 15644099. 
  9. ^ Höcht S, Grüning G, Allgoewer I, Nausner M, Brunnberg L, Hinkelbein W (2002). "[Treatment of keratitis superficialis chronica of the dog with strontium 90]". Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al.] 178 (2): 99–104. PMID 11942044. 
  10. ^ Thornton, Kim Campbell (2006-07-17). "Shades for Scruffy? Canine eyewear not just for being a doggie diva". MSNBC. http://www.msnbc.msn.com/id/13820336/. Retrieved 2007-04-28. 

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • chronic superficial keratitis — bilateral cellular infiltration and vascularization of the corneas in dogs, usually beginning at the lateral corner and progressing towards the middle so that the cornea becomes pigmented. Since it is limited to German shepherds and a few other… …   Medical dictionary

  • Keratitis — Classification and external resources An eye with non ulcerative sterile keratitis. ICD 10 H16 …   Wikipedia

  • Chronic progressive external ophthalmoplegia — Classification and external resources ICD 10 H49.4 ICD 9 378.72 …   Wikipedia

  • Uberreiter syndrome — chronic superficial keratitis …   Medical dictionary

  • Pannus — For the eye disease in dogs, see Chronic superficial keratitis. Pannus is a medical term for an abnormal layer of fibrovascular tissue or granulation tissue. Common sites for pannus formation include over the cornea, over a joint surface (as seen …   Wikipedia

  • degenerative pannus — pannus degenerativus 1. growth of connective tissue between the epithelium of the cornea and Bowman membrane. 2. chronic superficial keratitis …   Medical dictionary

  • List of cutaneous conditions — This is an incomplete list, which may never be able to satisfy particular standards for completeness. You can help by expanding it with reliably sourced entries. See also: Cutaneous conditions, Category:Cutaneous conditions, and ICD 10… …   Wikipedia

  • List of dog diseases — This list of dog diseases is a continuously updated selection of diseases and other conditions found in the dog. Some of these diseases are unique to dogs or closely related species, while others are found in other animals, including humans. Not… …   Wikipedia

  • Onchocerciasis — River Blindness redirects here. For the song by J. Geils Band, see Freeze Frame (J. Geils Band album). Onchocerciasis Classification and external resources Adult black fly (Simulium yahense) with parasite (Onchocerca volvulus) emerging from the… …   Wikipedia

  • Herpetic keratoconjunctivitis — Herpesviral ocular disease Classification and external resources ICD 10 B00.5 ICD 9 054.4 …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.