CC chemokine receptors


CC chemokine receptors

protein
Name = CCR1
caption =


width =
HGNCid =1602
Symbol = CCR1
AltSymbols =
EntrezGene = 1230
OMIM = 601159
RefSeq = NM_001295
UniProt = P32246
PDB =
ECnumber =
Chromosome = 3
Arm = p21
Band =
LocusSupplementaryData =

protein
Name = CCR2
caption =


width =
HGNCid =1603
Symbol = CCR2
AltSymbols =
EntrezGene = 1231
OMIM = 601268
RefSeq = NM_000647
UniProt = P41597
PDB = 1KAD
ECnumber =
Chromosome = 3
Arm = p21
Band =
LocusSupplementaryData =

protein
Name = CCR3
caption =


width =
HGNCid =1604
Symbol = CCR3
AltSymbols =
EntrezGene = 1232
OMIM = 601268
RefSeq = NM_001837
UniProt = P51677
PDB =
ECnumber =
Chromosome = 3
Arm = p21
Band =
LocusSupplementaryData =

protein
Name = CCR4
caption =


width =
HGNCid =1605
Symbol = CCR4
AltSymbols =
EntrezGene = 1233
OMIM = 604836
RefSeq = NM_005508
UniProt = P51679
PDB =
ECnumber =
Chromosome = 3
Arm = p24
Band =
LocusSupplementaryData =

protein
Name = CCR5
caption =


width =
HGNCid =1606
Symbol = CCR5
AltSymbols =
EntrezGene = 1234
OMIM = 601373
RefSeq = NM_000579
UniProt = P51681
PDB = 1ND8
ECnumber =
Chromosome = 3
Arm = p21
Band =
LocusSupplementaryData =

protein
Name = CCR6
caption =


width =
HGNCid =1607
Symbol = CCR6
AltSymbols =
EntrezGene = 1235
OMIM = 601835
RefSeq = NM_004367
UniProt = P51684
PDB =
ECnumber =
Chromosome = 6
Arm = q27
Band =
LocusSupplementaryData =

protein
Name = CCR7
caption =


width =
HGNCid =1608
Symbol = CCR7
AltSymbols =
EntrezGene = 1236
OMIM = 600242
RefSeq = NM_001838
UniProt = P32248
PDB =
ECnumber =
Chromosome = 17
Arm = q12-q21.2
Band =
LocusSupplementaryData =

protein
Name = CCR8
caption =


width =
HGNCid =1609
Symbol = CCR8
AltSymbols =
EntrezGene = 1237
OMIM = 601834
RefSeq = NM_005201
UniProt = P51685
PDB =
ECnumber =
Chromosome = 3
Arm = p22
Band =
LocusSupplementaryData =

protein
Name = CCR9
caption =


width =
HGNCid =1610
Symbol = CCR9
AltSymbols =
EntrezGene = 10803
OMIM = 604738
RefSeq = NM_031200
UniProt = P51686
PDB =
ECnumber =
Chromosome = 3
Arm = p21
Band =
LocusSupplementaryData =

protein
Name = CCR10
caption =


width =
HGNCid =4474
Symbol = CCR10
AltSymbols =
EntrezGene = 2826
OMIM = 600240
RefSeq = NM_016602
UniProt = P46092
PDB =
ECnumber =
Chromosome = 17
Arm = 17q21.1-q21
Band =
LocusSupplementaryData =

CC chemokine receptors are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. To date, ten true members of the CC chemokine receptor subfamily have been described. These are named CCR1 to CCR10 according to the IUIS/WHO Subcommittee on Chemokine Nomenclature.

Mechanism

The CC chemokine receptors all work by activating the G protein Gi [ [http://senselab.med.yale.edu/NeuronDB/receptors2.asp#Chemokine%20receptors,CC senselab] ] .

Types

Overview table

CCR1

CCR1 was the first CC chemokine receptor identified and binds multiple inflammatory/inducible (see inducible gene) CC chemokines (including CCL4, CCL5, CCL6, CCL14, CCL15, CCL16 and CCL23). [Ma et al. The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2004 Feb 1;172(3):1872-81.] Youn et al Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J. Immun. 159: 5201-5205, 1997.] Nomiyama et al. Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes. Int Immunol. 2001 Aug;13(8):1021-9.] [Berahovich et al. Proteolytic Activation of Alternative CCR1 Ligands in Inflammation. J. Immunol. 174:7341-7351, 2005.] In humans, this receptor can be found on peripheral blood lymphocytes and monocytes. There is some suggestion that this chemokine receptor is restricted to memory T-cells within the lymphocyte pool. This receptor is also designated cluster of differentiation marker CD191.

CCR2

CCR2 can interact with CCL2, CCL8 and CCL16 and has been identified on the surface of monocytes, activated memory T cells, B cells, and basophils in humans, and also in peritoneal macrophages in mice.Ogilvie et al. Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5. Blood. 2001, 97:1920-4 ] CCR2 is also designated CD192.

CCR3

CCR3 is a receptor for multiple inflammatory/inducible CC chemokines, including CCL11, CCL26, CCL7, CCL13, CCL15, CCL24 and CCL5 that attract eosinophils, and CCL28 that attracts B and T lymphocytes to mucosal tissues. [Kitaura et al. Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. J. Biol. Chem. 1996, 271:7725-7730.] [Kitaura et al. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J. Biol. Chem. 274:27975-27980, 1999.] Pan et al. 2000, A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues, J. Immunol. 165: 2943–2949.] [White et al. Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. J. Leukoc. Biol. 62:667-675, 1997.] It is most highly expressed in both eosinophils and basophils, but can also be found in Th1 and Th2 cells and airway epithelial cells. Thus CCR3 plays a role in allergic reactions. CCR3 is also known as CD193.

CCR4

CCR4 is expressed on Th2 T lymphocytes and is up-regulated by T cell receptor activation. However, some reports suggest a role for this receptor also in trafficking of dendritic cells. The CC chemokines CCL3, CCL5, CCL17 and CCL22 signal through this receptor. [Imai et al. The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. J. Biol. Chem. 272: 15036-15042, 1997. ] [Imai et al. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. J. Biol. Chem. 273:1764-1768 (1998).]

CCR5

CCR5 is expressed on several cell types including peripheral blood-derived dendritic cells, CD34+ hematopoietic progenitor cells and certain activated/memory Th1 lymphocytes. This receptor is well defined as a major coreceptor implicated in susceptibility to HIV-1 infection and disease. This receptor has several CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14 and CCL16. [Gong et al., Monocyte Chemotactic Protein-2 Activates CCR5 and Blocks CD4/CCR5-mediated HIV-1 Entry/Replication. J Biol Chem, 1998, 273,4289-4292.] [Blanpain et al., CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999, 94:1899-905.]

CCR6

CCR6, a receptor for CCL20, is expressed on unactivated memory T-cells and some dendritic cells. CCR6 is also expressed on Th17 cells. [Acosta-Rodriguez et al., Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells. Nat. Immunology, 2007, 6, 639-646.] CCR6 is down-regulated in activated T-cells. [Baba et al., Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J Biol Chem. 1997, 272:14893-8.]

CCR7

CCR7 is a highly important receptor with a role in trafficking of B and T lymphocytes and dendritic cells to and across high endothelial venules and positioning those cells correctly in T cell zones of secondary lymphoid organs. Its ligands include the related chemokines CCL19 and CCL21, (previously called ELC and SLC). [Yoshida et al. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific ligand for EBI1, CCR7. J. Biol. Chem. 272: 13803-13809, 1997. ]

CCR8

CCR8 is associated with Th2 lymphocytes and is therefore found predominantly in the thymus (in humans) although some expression can be found in the brain, spleen, lymph node, and monocytes at the nucleotide level. The ligands for this receptor are CCL1 and CCL16. [Roos et al., Identification of CCR8, the receptor for the human CC chemokine I-309. J Biol Chem 1997 Vol 272, 17251–4. ]

CCR9

CCR9 was previously called orphan receptor GPR 9-6 and is very highly expressed in thymus (on both immature and mature T-cells) while low in lymph nodes and spleen. CCR9 is also abundant in the gut, with its expression associated with T cells of the intestine. The specific ligand of this receptor is CCL25. [Zaballos et al., Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. J. Immunol., 1999, 162:5671-5675.] To note, the chemokine binding protein D6 had previously been named CCR9, but this molecule is a scavenger receptor not a true (signaling) chemokine receptor.

CCR10

CCR10 is receptor for CCL27 and CCL28 that was originally called orphan receptor GPR2. [Gosling et al., Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J Immunol. 2000, 164:2851-6.] [Homey et al. The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J. Immunol. 164:3465-3470, 2000.] [Wang et al. 2000, Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J. Biol. Chem. 275: 22313–22323.] CCR10 has been implicated in inflammation of the skin, and has been shown to recruit regulatory T cells (Tregs) to mucosal layers.

CCR11

This molecule was originally designated CCR11 due to its ability to bind several CC chemokines (including CCL19, CCL21 and CCL25) and its structural similarity to chemokine receptors. However, due to the inability of this molecule (also known as CCRL1 and CCX CKR) to generate a signal following ligand interaction, it has been suggested that it is a scavenger receptor for chemokines and not a bonafide chemokine receptor. Thus CCRL1 should not be called CCR11 under the guidelines of the IUIS/WHO Subcommittee on Chemokine Nomenclature.

References


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • chemokine receptors — are G protein linked serpentine receptors that, in addition to binding chemokines, are used as co receptors for the binding of immunodeficiency viruses (HIV, SIV, FIV) to leucocytes. CXCR4 is a co receptor for T tropic viruses, CCR5 for… …   Dictionary of molecular biology

  • CXC chemokine receptors — CXCR1 Identifiers Symbol IL8RA Entrez 3577 OMIM …   Wikipedia

  • Chemokine receptor — Typical structure of a chemokine receptor, with seven transmembrane domains and a characteristic DRY motif in the second intracellular domain. Chemokine receptors are usually linked to a G protein through which they signal. Chemokine receptors… …   Wikipedia

  • Chemokine — Small cytokines (intecrine/chemokine), interleukin 8 like Solution structure of interleukin 8, a chemokine of the CXC subfamily Identifiers Symbol IL8 …   Wikipedia

  • Chemokine receptor — A molecule that receives a chemokine and a chemokine dock. A chemokine is a protein that acts as a lure. Chemokines are involved in inflammation, cancer, and infectious diseases. Several chemokine receptors are essential coreceptors for HIV …   Medical dictionary

  • Chemokine — One of a large group of proteins that act as lures and were first found attracting white blood cells. The chemokines are involved in a wide variety of processes including acute and chronic types of inflammation, infectious diseases, and cancer.… …   Medical dictionary

  • chemokine — ˌ noun ( s) Etymology: chem + kine (as in cytokine herein) : any of a group of chemotactic cytokines that are produced by various cells (as at sites of inflammation), that are thought to provide directional cues for the movement of white blood… …   Useful english dictionary

  • C-C chemokine receptor type 7 — Chemokine (C C motif) receptor 7 Identifiers Symbols CCR7; BLR2; CD197; CDw197; CMKBR7; EBI1 External IDs …   Wikipedia

  • C-C chemokine receptor type 6 — Chemokine receptor 6 (gene name CCR6) is a human CC chemokine receptor.CCR6 has also recently been designated CD196 (cluster of differentiation 196). PBB Summary section title = summary text = This protein belongs to family A of G protein coupled …   Wikipedia

  • Rhodopsin-like receptors — Pfam box Symbol = 7tm 1 Name = Rhodopsin like receptors width = caption = Pfam= PF00001 InterPro= IPR000276 SMART= PROSITE = PDOC00211 SCOP = 1f88 TCDB = OPM family= 6 OPM protein= 1gzm PDB=Rhodopsin like receptors are the largest group of G… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.