Coenzyme B


Coenzyme B
Coenzyme B
Identifiers
CAS number 104302-77-4
PubChem 350
ChemSpider 343 YesY
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C11H22NO7PS
Molar mass 343.333641
 YesY B (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Coenzyme B is a coenzyme required for redox reactions in methanogens. The full chemical name of coenzyme B is 7-mercaptoheptanoylthreoninephosphate.[1] The molecule contains a thiol, which is its principal site of reaction.

Coenzyme B reacts with 2-methylthioethanesulfonate (methyl-Coenzyme M, abbreviated CH3–S–CoM), to release methane in methanogenesis:[2]

CH3–S–CoM + HS–CoB → CH4 + CoB–S–S–CoM

This conversion is catalyzed by the enzyme methyl coenzyme M reductase, which contains cofactor F430 as the prosthetic group.

A related conversion that utilizes both HS-CoB and HS-CoM is the reduction of fumarate to succinate, catalyzed by fumarate reductase:[3]

CH3–S–CoM + HS–CoB O2CCH=CHCO
2
O2CCH2–CH2CO
2
+ CoB–S–S–CoM

References



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  • coenzyme — co*en zyme (k[ o]*[e^]n z[imac]m), (Biochem.) a molecule that is essential for the activity of some enzymes; it may exist free in solution within a living organism, but functions by binding to an enzyme to assist in catalyzing a reaction. The… …   The Collaborative International Dictionary of English

  • coenzyme A — coenzyme A. См. кофермент А. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • coenzyme Q — coenzyme Q. См. убихинон. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.


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