Decay accelerating factor


Decay accelerating factor

Decay accelerating factor (CD55) is a 70 kDa membrane protein that regulates the complement system on the cell surface. It prevents the assembly of the C3bBb complex (the C3-convertase of the alternative pathway) or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.

This glycoprotein is broadly distributed among hematopoietic and non-hematopoietic cells. It is a determinant for the Cromer blood group system.

Pathology

DAF is not expressed on paroxysmal nocturnal hemoglobinuria III (markedly abnormal) RBCs; however, this deficiency is not the cause of PNH.

ee also

* List of human clusters of differentiation

Further reading

PBB_Further_reading
citations =
*cite journal | author=Selinka HC, Wolde A, Sauter M, "et al." |title=Virus-receptor interactions of coxsackie B viruses and their putative influence on cardiotropism. |journal=Med. Microbiol. Immunol. |volume=193 |issue= 2-3 |pages= 127–31 |year= 2004 |pmid= 12920584 |doi= 10.1007/s00430-003-0193-y
*cite journal | author=Mikesch JH, Schier K, Roetger A, "et al." |title=The expression and action of decay-accelerating factor (CD55) in human malignancies and cancer therapy. |journal=Cell. Oncol. |volume=28 |issue= 5-6 |pages= 223–32 |year= 2007 |pmid= 17167176 |doi=

External links

*
* [http://www.ncbi.nlm.nih.gov/projects/mhc/xslcgi.fcgi?cmd=bgmut/systems_info&system=cromer Cromer blood group system at BGMUT] , Blood Group Antigen Gene Mutation Database at NCBI, NIH

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